Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma. (Q38151195)

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27 February 2020

title

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma (English)

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27 February 2020

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1

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27 February 2020

author name string

Samuel A Okubote

series ordinal

2

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Hana Svachova

series ordinal

3

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27 February 2020

language of work or name

English

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publication date

20 September 2013

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British Journal of Haematology

27 February 2020

published in

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volume

163

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issue

5

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page(s)

551-564

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Multiple myeloma: a paradigm for translation of the cancer stem cell hypothesis

27 February 2020

cites work

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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

21 January 2018

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Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.

21 January 2018

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The search for multiple myeloma stem cells: the long and winding road

21 January 2018

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CD117 (c-kit) is aberrantly expressed in a subset of MGUS and multiple myeloma with unexpectedly good prognosis

21 January 2018

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Chromosome translocations in multiple myeloma

21 January 2018

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Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

21 January 2018

1 reference

The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell

21 January 2018

1 reference

Plasma cells: finding new light at the end of B cell development

21 January 2018

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Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

21 January 2018

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Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma.

21 January 2018

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AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

21 January 2018

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Characterization of potential CD138 negative myeloma "stem cells".

21 January 2018

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Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

21 January 2018

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Immunity to stemness genes in human cancer

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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

21 January 2018

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Primary Bioassay of Human Myeloma Stem Cells

21 January 2018

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Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency

21 January 2018

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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

21 January 2018

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Hypoxia inducible factors in cancer stem cells

21 January 2018

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Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

21 January 2018

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Multiple myeloma cancer stem cells

21 January 2018

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Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications

21 January 2018

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Sequential maturation stages of monoclonal B lineage cells from blood, spleen, lymph node, and bone marrow from a terminal myeloma patient

21 January 2018

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Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

21 January 2018

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Clonal competition with alternating dominance in multiple myeloma.

21 January 2018

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CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells.

21 January 2018

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Enhancement of clonogenicity of human multiple myeloma by dendritic cells

21 January 2018

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Immunophenotyping in multiple myeloma and related plasma cell disorders

21 January 2018

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Induction of multilineage markers in human myeloma cells and their down-regulation by interleukin 6.

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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Cell plasticity and heterogeneity in cancer.

21 January 2018

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Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.

21 January 2018

1 reference

HIF induces human embryonic stem cell markers in cancer cells.

21 January 2018

1 reference

Characterization of clonogenic multiple myeloma cells

21 January 2018

1 reference

Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance

21 January 2018

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Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

21 January 2018

1 reference

Demystifying SP cell purification: viability, yield, and phenotype are defined by isolation parameters.

21 January 2018

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Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2.

21 January 2018

1 reference

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

21 January 2018

1 reference

Short-lived and long-lived bone marrow plasma cells are derived from a novel precursor population.

21 January 2018

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CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype

21 January 2018

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Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

21 January 2018

1 reference

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

Circulating clonotypic B cells in the biology of multiple myeloma: speculations on the origin of myeloma

21 January 2018

1 reference

Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm

21 January 2018

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In multiple myeloma clonotypic CD38- /CD19+ / CD27+ memory B cells recirculate through bone marrow, peripheral blood and lymph nodes.

21 January 2018

1 reference

Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma

21 January 2018

1 reference

Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone

21 January 2018

1 reference

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

21 January 2018

1 reference

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.

21 January 2018

1 reference

Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

21 January 2018

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Detection, isolation and characterization of principal synthetic route indicative impurities in verapamil hydrochloride

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

CD20-Directed Serotherapy in Patients With Multiple Myeloma: Biologic Considerations and Therapeutic Applications

21 January 2018

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Phenotypic detection of clonotypic B cells in multiple myeloma by specific immunoglobulin ligands reveals their rarity in multiple myeloma

21 January 2018

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Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms

21 January 2018

1 reference

Side population cells in human cancers

21 January 2018

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Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

21 January 2018

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The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype

21 January 2018

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Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/BJH.12563

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24111932%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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