Systems pharmacology modeling: an approach to improving drug safety (Q38153621)

29 August 2017

title

Systems pharmacology modeling: an approach to improving drug safety (English)

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29 August 2017

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3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Jane P F Bai

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Robert J Fontana

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Vineet Sangar

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

20 November 2013

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Biopharmaceutics and Drug Disposition

29 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

35

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24136298%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

1

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2 June 2020

page(s)

1-14

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Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry

2 June 2020

cites work

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Systems biology and new technologies enable predictive and preventative medicine.

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Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins

21 January 2018

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Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells

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Systems pharmacology to predict drug toxicity: integration across levels of biological organization

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Proton pump inhibitors and severe hypomagnesaemia.

21 January 2018

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Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis. 1. Oral absorption of magnesium

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Charge-selective claudin channels

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The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens

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Transcriptional regulation of the claudin-16 gene by Mg2+ availability

21 January 2018

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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

21 January 2018

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Sequence and organization of the human mitochondrial genome

21 January 2018

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Mitochondrial respiratory-chain diseases

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A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle

21 January 2018

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A systems biology framework identifies molecular underpinnings of coronary heart disease

21 January 2018

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Association between statin-associated myopathy and skeletal muscle damage

21 January 2018

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Cerivastatin, genetic variants, and the risk of rhabdomyolysis

21 January 2018

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Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks

21 January 2018

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Assessment of clinical analytical sensitivity and specificity of next-generation sequencing for detection of simple and complex mutations

21 January 2018

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Molecular imaging: challenges of bringing imaging of intracellular targets into common clinical use.

21 January 2018

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A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology

21 January 2018

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

21 January 2018

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Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity

21 January 2018

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High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes

21 January 2018

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Tetracycline-associated fatty liver in the male. Report of an autopsied case

21 January 2018

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Hepatic steatosis and lactic acidosis caused by stavudine in an HIV-infected patient

21 January 2018

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In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis

21 January 2018

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Are statin medications safe in patients with ALS?

21 January 2018

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Selected statins produce rapid spinal motor neuron loss in vitro.

21 January 2018

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Reversible inhibition of mitochondrial protein synthesis during linezolid-related hyperlactatemia

21 January 2018

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Mitochondria death/survival signaling pathways in cardiotoxicity induced by anthracyclines and anticancer-targeted therapies

21 January 2018

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Withdrawal of cerivastatin from the world market

21 January 2018

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Signal transduction pathways involved in drug-induced liver injury

21 January 2018

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Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure

21 January 2018

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

21 January 2018

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Transforming growth factor-β, bioenergetics, and mitochondria in renal disease

21 January 2018

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2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways

21 January 2018

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Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

21 January 2018

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Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.

21 January 2018

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Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.

21 January 2018

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Synergistic heterozygosity: disease resulting from multiple partial defects in one or more metabolic pathways

21 January 2018

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Walking the interactome for prioritization of candidate disease genes

21 January 2018

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21 January 2018

Rhabdomyolysis: a review

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Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors

21 January 2018

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Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency

21 January 2018

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Genetic risk factors associated with lipid-lowering drug-induced myopathies

21 January 2018

1 reference

Mechanisms of drug-induced liver injury: from bedside to bench

21 January 2018

1 reference

Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

21 January 2018

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Mitochondrial nitric oxide in the signaling of cell integrated responses

21 January 2018

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Pharmacologic effects on mitochondrial function

21 January 2018

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases

21 January 2018

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Reactive oxygen species: role in the development of cancer and various chronic conditions

21 January 2018

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Reactive oxygen species in oncogenic transformation

21 January 2018

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The role of oxidative stress in carcinogenesis

21 January 2018

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

1 reference

A community-driven global reconstruction of human metabolism.

21 January 2018

1 reference

Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

21 January 2018

1 reference

Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT

21 January 2018

1 reference

Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolism

21 January 2018

1 reference

New epidemiologic evidence confirming that bias does not explain the aspirin/Reye's syndrome association

21 January 2018

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Valproic acid hepatic fatalities. III. U.S. experience since 1986.

21 January 2018

1 reference

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 January 2018

1 reference

Metabolic acidosis and hepatic steatosis in two HIV-infected patients on stavudine (d4T) treatment

21 January 2018

1 reference

Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy

21 January 2018

1 reference

Linezolid-induced inhibition of mitochondrial protein synthesis.

21 January 2018

1 reference