The role of hypoxia in stem cell potency and differentiation (Q38154615)

29 August 2017

The role of hypoxia in stem cell potency and differentiation (English)

1 reference

29 August 2017

Kate E Hawkins

1

1 reference

PubMed ID

24147532

29 August 2017

Tyson V Sharp

series ordinal

2

1 reference

PubMed ID

24147532

29 August 2017

Tristan R McKay

series ordinal

3

1 reference

29 August 2017

1 November 2013

1 reference

29 August 2017

Regenerative Medicine

1 reference

29 August 2017

8

1 reference

29 August 2017

771-782

1 reference

29 August 2017

6

1 reference

Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia.

29 August 2017

1 reference

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

1 reference

Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions

21 January 2018

1 reference

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

21 January 2018

1 reference

The impact of O2 availability on human cancer

21 January 2018

1 reference

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

1 reference

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

21 January 2018

1 reference

Oxygen in the cultivation of stem cells

21 January 2018

1 reference

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function.

21 January 2018

1 reference

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

21 January 2018

1 reference

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

21 January 2018

1 reference

ARNT-deficient mice and placental differentiation

21 January 2018

1 reference

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

21 January 2018

1 reference

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

21 January 2018

1 reference

Molecular control of pluripotency

21 January 2018

1 reference

The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming

21 January 2018

1 reference

Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

1 reference

Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.

21 January 2018

1 reference

Low O2 tensions and the prevention of differentiation of hES cells

21 January 2018

1 reference

Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts

21 January 2018

1 reference

Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells

21 January 2018

1 reference

A reduced oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in the undifferentiated state with short splitting intervals

21 January 2018

1 reference

Self-renewal and pluripotency is maintained in human embryonic stem cells by co-culture with human fetal liver stromal cells expressing hypoxia inducible factor 1alpha

21 January 2018

1 reference

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

21 January 2018

1 reference

FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.

21 January 2018

1 reference

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

21 January 2018

1 reference

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

21 January 2018

1 reference

Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.

21 January 2018

1 reference

Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia.

21 January 2018

1 reference

LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells

21 January 2018

1 reference

Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

21 January 2018

1 reference

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

21 January 2018

1 reference

Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF.

21 January 2018

1 reference

Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor.

21 January 2018

1 reference

Hypoxia enhances the generation of retinal progenitor cells from human induced pluripotent and embryonic stem cells.

21 January 2018

1 reference

Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality

21 January 2018

1 reference

Hypoxia-driven proliferation of embryonic neural stem/progenitor cells--role of hypoxia-inducible transcription factor-1alpha

21 January 2018

1 reference

Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning

21 January 2018

1 reference

Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha

21 January 2018

1 reference

Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases

21 January 2018

1 reference

Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

1 reference

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

21 January 2018

1 reference

Long-term repopulating hematopoietic stem cells and "side population" in human steady state peripheral blood.

21 January 2018

1 reference

The hematopoietic stem cell niche: low in oxygen but a nice place to be.

21 January 2018

1 reference

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

21 January 2018

1 reference

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

21 January 2018

1 reference

Redox regulation of stem cell mobilization

21 January 2018

1 reference

Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells.

21 January 2018

1 reference

Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow

21 January 2018

1 reference

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

21 January 2018

1 reference

Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

21 January 2018

1 reference

HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency

21 January 2018

1 reference

Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells

21 January 2018

1 reference

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.

21 January 2018

1 reference

Functional stability (at +4°C) of hematopoietic stem and progenitor cells amplified ex vivo from cord blood CD34+ cells

21 January 2018

1 reference

Clinical-scale cultures of cord blood CD34(+) cells to amplify committed progenitors and maintain stem cell activity.

21 January 2018

1 reference

Marrow stromal cells as stem cells for nonhematopoietic tissues

21 January 2018

1 reference

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

21 January 2018

1 reference

Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia

21 January 2018

1 reference

Mesenchymal stem cells and their potential as cardiac therapeutics

21 January 2018

1 reference

Stem cell therapy in cardiology

21 January 2018

1 reference

Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells

21 January 2018

1 reference

Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

21 January 2018

1 reference

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

21 January 2018

1 reference

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia

21 January 2018

1 reference

Survival and function of mesenchymal stem cells (MSCs) depend on glucose to overcome exposure to long-term, severe and continuous hypoxia

21 January 2018

1 reference

Role of HIF-1alpha and VEGF in human mesenchymal stem cell proliferation by 17beta-estradiol: involvement of PKC, PI3K/Akt, and MAPKs

21 January 2018

1 reference

Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.

21 January 2018

1 reference

Autocrine fibroblast growth factor 2-mediated interactions between human mesenchymal stem cells and the extracellular matrix under varying oxygen tension

21 January 2018

1 reference

HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

21 January 2018

1 reference

Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha.

21 January 2018

1 reference

Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells

21 January 2018

1 reference

Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering

21 January 2018

1 reference

Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions.

21 January 2018

1 reference

Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling

21 January 2018

1 reference

Oxygenated environment enhances both stem cell survival and osteogenic differentiation

21 January 2018

1 reference

Tissue oxygen tension and brain sensitivity to hypoxia

21 January 2018

1 reference

Astrocytic stem cells in the adult brain

21 January 2018

1 reference

A specialized vascular niche for adult neural stem cells.

21 January 2018

1 reference

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

21 January 2018

1 reference

The neurogenic niche in the carotid body and its applicability to antiparkinsonian cell therapy.

21 January 2018

1 reference

Hypoxia-inducible factors and the response to hypoxic stress

21 January 2018

1 reference

Nuclear orphan receptor TLX induces Oct-3/4 for the survival and maintenance of adult hippocampal progenitors upon hypoxia

21 January 2018

1 reference

TLX controls angiogenesis through interaction with the von Hippel-Lindau protein

21 January 2018

1 reference

Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling

21 January 2018

1 reference

Hypoxia requires notch signaling to maintain the undifferentiated cell state

21 January 2018

1 reference

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

21 January 2018

1 reference

O2 regulates stem cells through Wnt/β-catenin signalling.

21 January 2018

1 reference

Hypoxia/reoxygenation stimulates proliferation through PKC-dependent activation of ERK and Akt in mouse neural progenitor cells.

21 January 2018

1 reference

Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro

21 January 2018

1 reference

Mild hypoxia enhances proliferation and multipotency of human neural stem cells

21 January 2018

1 reference

Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism

21 January 2018

1 reference

Current challenges for the advancement of neural stem cell biology and transplantation research.

21 January 2018

1 reference

Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection

21 January 2018

1 reference

Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/RME.13.71

1 reference

29 August 2017

1 reference

PubMed ID

24147532