The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation (Q38169097)

30 August 2017

title

The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation (English)

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30 August 2017

Arthur D Moes

1

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30 August 2017

Nils van der Lubbe

2

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30 August 2017

Robert Zietse

3

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30 August 2017

Johannes Loffing

4

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30 August 2017

Ewout J Hoorn

5

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30 August 2017

publication date

6 December 2013

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30 August 2017

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30 August 2017

volume

466

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30 August 2017

issue

1

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30 August 2017

page(s)

107-118

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Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels

30 August 2017

cites work

1 reference

12 December 2020

Reduced content of alpha subunit of Gq protein content in monocytes of Bartter and Gitelman syndromes: relationship with vascular hyporeactivity

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12 December 2020

Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure

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12 December 2020

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

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12 December 2020

SPAK differentially mediates vasopressin effects on sodium cotransporters.

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12 December 2020

Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone

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12 December 2020

Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia

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12 December 2020

Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.

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12 December 2020

Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin

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12 December 2020

Familial hyperkalemic hypertension

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12 December 2020

Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport

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12 December 2020

Interdependence of Active Na+ and Cl- transport by the isolated urinary bladder of the teleost, Pseudopleuronectes americanus

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12 December 2020

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

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12 December 2020

Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet

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12 December 2020

Thiazide-sensitive sodium chloride cotransport in early distal tubule

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12 December 2020

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

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12 December 2020

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

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12 December 2020

Dietary magnesium, not calcium, regulates renal thiazide receptor

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12 December 2020

Identification and proteomic profiling of exosomes in human urine

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12 December 2020

Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

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12 December 2020

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway

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12 December 2020

Hypokalemia in a mouse model of Gitelman's syndrome

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12 December 2020

Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats

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12 December 2020

The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer.

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12 December 2020

An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis

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12 December 2020

Novel NCC mutants and functional analysis in a new cohort of patients with Gitelman syndrome

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12 December 2020

Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status

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12 December 2020

Spectrum of mutations in Gitelman syndrome

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12 December 2020

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

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12 December 2020

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

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12 December 2020

K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter

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12 December 2020

Angiotensin II inhibits the ROMK-like small conductance K channel in renal cortical collecting duct during dietary potassium restriction

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12 December 2020

WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron

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12 December 2020

Conservation of Na+ vs. K+ by the rat cortical collecting duct

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12 December 2020

Molecular physiology of cation-coupled Cl? cotransport: the SLC12 family

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12 December 2020

Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway

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12 December 2020

WNK kinases and the kidney

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12 December 2020

Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium/chloride cotransporter

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12 December 2020

RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter

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12 December 2020

Absence of vascular remodelling in a high angiotensin-II state (Bartter's and Gitelman's syndromes): implications for angiotensin II signalling pathways

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12 December 2020

Renal and brain isoforms of WNK3 have opposite effects on NCCT expression

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12 December 2020

Phosphorylation regulates NCC stability and transporter activity in vivo

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12 December 2020

Metabolic acidosis has dual effects on sodium handling by rat kidney

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12 December 2020

The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs

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12 December 2020

Prospects for urinary proteomics: exosomes as a source of urinary biomarkers

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12 December 2020

Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter

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12 December 2020

Genotype, phenotype, and follow-up in Taiwanese patients with salt-losing tubulopathy associated with SLC12A3 mutation

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12 December 2020

WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway

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12 December 2020

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

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12 December 2020

Use of diuretics in patients with hypertension

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12 December 2020

Thiazide-sensitive NaCl-cotransporter in the intestine: possible role of hydrochlorothiazide in the intestinal Ca2+ uptake.

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12 December 2020

Aldosterone paradox: differential regulation of ion transport in distal nephron.

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12 December 2020

Number and function of circulating endothelial progenitor cells and calcitonin gene-related peptide in hypertension: support from and opportunities in Bartter's and Gitelman's syndromes patients

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12 December 2020

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

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12 December 2020

The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4.

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12 December 2020

Exploring the intricate regulatory network controlling the thiazide-sensitive NaCl cotransporter (NCC).

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12 December 2020

Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule

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12 December 2020

Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron

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12 December 2020

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved

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12 December 2020

11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.

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12 December 2020

Fifty years of thiazide diuretic therapy for hypertension

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12 December 2020

Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney

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12 December 2020

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

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12 December 2020

Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.

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12 December 2020

Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding

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12 December 2020

Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule

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12 December 2020

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

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12 December 2020

A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters

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12 December 2020

The renal tubular Na-Cl co-transporter (NCCT): a potential genetic link between blood pressure and bone density?

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12 December 2020

Thiazide-induced vasodilation in humans is mediated by potassium channel activation

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12 December 2020

Sodium chloride absorption by the urinary bladder of the winter flounder. A thiazide-sensitive, electrically neutral transport system

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12 December 2020

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

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12 December 2020

2009 Homer W. Smith Award: Minerals in motion: from new ion transporters to new concepts

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12 December 2020

Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins

1 reference

12 December 2020

Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis

1 reference

12 December 2020

Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3)

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12 December 2020

Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule in ovariectomized rats

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12 December 2020

Hyponatremia revisited: translating physiology to practice

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12 December 2020

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

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12 December 2020

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

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12 December 2020

N-Glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na(+):Cl(-) cotransporter.

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12 December 2020

A SPAK isoform switch modulates renal salt transport and blood pressure

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12 December 2020

Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition

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12 December 2020

Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

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12 December 2020

Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney

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12 December 2020

Insulin increases the functional activity of the renal NaCl cotransporter

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12 December 2020

SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.

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12 December 2020

Cyclosporine metabolic side effects: association with the WNK4 system

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12 December 2020

The WNK kinase network regulating sodium, potassium, and blood pressure

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12 December 2020

Mutations in the chloride channel gene CLCNKB as a cause of classic Bartter syndrome

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12 December 2020

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

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12 December 2020

The WNKs: atypical protein kinases with pleiotropic actions.

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12 December 2020

Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension

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12 December 2020

Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone

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12 December 2020

Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

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12 December 2020

A thiazide test for the diagnosis of renal tubular hypokalemic disorders

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12 December 2020

The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein

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12 December 2020

Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium

1 reference

12 December 2020

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

1 reference

12 December 2020

Thiazide effects and adverse effects: insights from molecular genetics

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12 December 2020

A standard nomenclature for structures of the kidney. The Renal Commission of the International Union of Physiological Sciences (IUPS).

1 reference

12 December 2020

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice

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12 December 2020

The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism

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12 December 2020

Multigene kinase network, kidney transport, and salt in essential hypertension

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12 December 2020

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.

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12 December 2020

Disorders of calcium and magnesium balance: a physiology-based approach

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12 December 2020

Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.

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12 December 2020

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice

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12 December 2020

Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.

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12 December 2020

Human hypertension caused by mutations in WNK kinases

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12 December 2020

Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway

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12 December 2020

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

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12 December 2020

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12 December 2020

Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide

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12 December 2020

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

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12 December 2020

Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway.

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12 December 2020

Angiotensin II: a candidate for an aldosterone-independent mediator of potassium preservation during volume depletion.

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12 December 2020

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

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12 December 2020

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

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12 December 2020

Pathogenesis of calcineurin inhibitor-induced hypertension

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12 December 2020

Adaptation in Gitelman syndrome: "we just want to pump you up"

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12 December 2020

Clarification of the site of action of chlorothiazide in the rat nephron

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12 December 2020

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

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12 December 2020

Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment.

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12 December 2020

Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone

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12 December 2020

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

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12 December 2020

Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction

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12 December 2020

Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination

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12 December 2020

Hypertension after kidney transplantation: calcineurin inhibitors increase salt-sensitivity

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12 December 2020

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

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12 December 2020

Water and ion transport by the urinary bladder of the teleost Pseudopleuronectes americanus

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12 December 2020

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.

1 reference

12 December 2020

Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension

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12 December 2020

Role of the WNK-activated SPAK kinase in regulating blood pressure

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12 December 2020

Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome

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12 December 2020

Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule

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12 December 2020

Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules

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12 December 2020

Localization of the ROMK protein on apical membranes of rat kidney nephron segments.

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12 December 2020

Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation.

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12 December 2020

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

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12 December 2020

10.1007/S00424-013-1407-9

Identifiers

DOI

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Dimensions Publication ID

30 August 2017

1045366764

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