NOD proteins: regulators of inflammation in health and disease (Q38171221)

30 August 2017

NOD proteins: regulators of inflammation in health and disease (English)

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30 August 2017

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Dana J Philpott

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30 August 2017

Matthew T Sorbara

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30 August 2017

Susan J Robertson

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30 August 2017

Kenneth Croitoru

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30 August 2017

Stephen E Girardin

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30 August 2017

language of work or name

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13 December 2013

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Nature Reviews Immunology

30 August 2017

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30 August 2017

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30 August 2017

9-23

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30 August 2017

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Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

30 August 2017

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Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

21 January 2018

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An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

21 January 2018

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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The Nod-like receptor (NLR) family: a tale of similarities and differences

21 January 2018

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Identification of the critical residues involved in peptidoglycan detection by Nod1.

21 January 2018

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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

21 January 2018

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Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

21 January 2018

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

21 January 2018

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

21 January 2018

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RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

21 January 2018

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The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner

21 January 2018

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Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition

21 January 2018

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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

21 January 2018

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Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease

21 January 2018

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Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

21 January 2018

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TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

21 January 2018

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Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections

21 January 2018

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Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages

21 January 2018

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Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components

21 January 2018

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TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation

21 January 2018

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CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

21 January 2018

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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

21 January 2018

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NOD-like receptor activation by outer membrane vesicles from Vibrio cholerae non-O1 non-O139 strains is modulated by the quorum-sensing regulator HapR.

21 January 2018

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Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

21 January 2018

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Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation

21 January 2018

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pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling

21 January 2018

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Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers

21 January 2018

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hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

21 January 2018

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Cell-cell propagation of NF-κB transcription factor and MAP kinase activation amplifies innate immunity against bacterial infection.

21 January 2018

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Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

21 January 2018

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Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments.

21 January 2018

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Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment

21 January 2018

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Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

21 January 2018

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Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes

21 January 2018

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Nod-like receptors: sentinels at host membranes

21 January 2018

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

21 January 2018

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RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition

21 January 2018

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Role for erbin in bacterial activation of Nod2

21 January 2018

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A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling

21 January 2018

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GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors

21 January 2018

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Identification of an innate T helper type 17 response to intestinal bacterial pathogens.

21 January 2018

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Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model

21 January 2018

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Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection

21 January 2018

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The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment

21 January 2018

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Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

21 January 2018

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L-Ala-γ-D-Glu-meso-diaminopimelic acid (DAP) interacts directly with leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its int

21 January 2018

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Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member

21 January 2018

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A new CARD15 mutation in Blau syndrome

21 January 2018

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Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands

21 January 2018

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NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

21 January 2018

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Non-apoptotic role of BID in inflammation and innate immunity.

21 January 2018

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A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.

21 January 2018

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Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin

21 January 2018

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Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton

21 January 2018

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Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.

21 January 2018

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The intermediate filament protein, vimentin, is a regulator of NOD2 activity

21 January 2018

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Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1.

21 January 2018

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

21 January 2018

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Nod-like receptors in the control of intestinal inflammation.

21 January 2018

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The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes

21 January 2018

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Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection

21 January 2018

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Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation

21 January 2018

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Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

21 January 2018

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NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

21 January 2018

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Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.

21 January 2018

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Nod2-dependent Th2 polarization of antigen-specific immunity.

21 January 2018

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Unleashing the therapeutic potential of NOD-like receptors

21 January 2018

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Modulating immunity as a therapy for bacterial infections

21 January 2018

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Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

21 January 2018

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Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae

21 January 2018

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NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation

21 January 2018

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The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

21 January 2018

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The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands

21 January 2018

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Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.

21 January 2018

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A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

21 January 2018

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Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential

21 January 2018

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Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni

21 January 2018

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The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity

21 January 2018

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Listeria monocytogenes evades killing by autophagy during colonization of host cells

21 January 2018

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Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole.

21 January 2018

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Escape of intracellular Shigella from autophagy

21 January 2018

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The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

21 January 2018

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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis

21 January 2018

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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

21 January 2018

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Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

21 January 2018

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A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy

21 January 2018

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A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection

21 January 2018

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Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo

21 January 2018

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

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NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

21 January 2018

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Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

21 January 2018

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Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

21 January 2018

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Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis

21 January 2018

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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

21 January 2018

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T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii

21 January 2018

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Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.

21 January 2018

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Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes

21 January 2018

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Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

21 January 2018

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The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release.

21 January 2018

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Nucleotide-binding oligomerization domain 2 signaling promotes hyperresponsive macrophages and colitis in IL-10-deficient mice

21 January 2018

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A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.

21 January 2018

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

21 January 2018

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The gut microbiota in IBD.

21 January 2018

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Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice.

21 January 2018

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NOD1 variation, immunoglobulin E and asthma.

21 January 2018

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Association of NOD1 polymorphisms with atopic eczema and related phenotypes

21 January 2018

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CARD15 mutations in Blau syndrome

21 January 2018

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Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation

21 January 2018

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Blau syndrome, clinical and genetic aspects

21 January 2018

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The role of bacteria and pattern recognition receptors in GVHD

21 January 2018

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Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease.

21 January 2018

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NOD2 regulates hematopoietic cell function during graft-versus-host disease

21 January 2018

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Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European Prospective Investigation into Cancer-Eurgast cohort

21 January 2018

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Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection

21 January 2018

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Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans.

21 January 2018

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

21 January 2018

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Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release

21 January 2018

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Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

21 January 2018

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Common alleles that influence autophagy and the risk for inflammatory bowel disease

21 January 2018

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A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

21 January 2018

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XIAP mediates NOD signaling via interaction with RIP2

21 January 2018

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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

21 January 2018

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

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Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

21 January 2018

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Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

21 January 2018

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ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

21 January 2018

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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

21 January 2018

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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.

21 January 2018

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Nod2 is required for the regulation of commensal microbiota in the intestine

21 January 2018

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Nod2 is essential for temporal development of intestinal microbial communities.

21 January 2018

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The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis

21 January 2018

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Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer

21 January 2018

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Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases

21 January 2018

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Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation

21 January 2018

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Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis

21 January 2018

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PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation

21 January 2018

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Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan

21 January 2018

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Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis

21 January 2018

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Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis

21 January 2018

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NOD1 activators link innate immunity to insulin resistance

21 January 2018

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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.

21 January 2018

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Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity

21 January 2018

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Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients

21 January 2018

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Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

21 January 2018

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Altered gut microbiota composition in immune-impaired Nod2(-/-) mice

21 January 2018

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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

21 January 2018

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Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

31 March 2020

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Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation

31 March 2020

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Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome

31 March 2020

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Is BID required for NOD signalling?

31 March 2020

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31 March 2020

Yeretssian et al. reply

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TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation

31 March 2020

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Mouse Paneth cell antimicrobial function is independent of Nod2.

31 March 2020

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Paneth cell marker CD24 in NOD2 knockout organoids and in inflammatory bowel disease (IBD).

31 March 2020

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Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells

31 March 2020

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Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence

31 March 2020

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Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

31 March 2020

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12 December 2020

Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1-/-; Nod2-/- mice.

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12 December 2020

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis

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12 December 2020

NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer.

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12 December 2020

An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways

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12 December 2020

Identifiers

DOI

10.1038/NRI3565

1 reference

30 August 2017

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