Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis. (Q38176187)

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4 March 2020

title

Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24394345%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

4 March 2020

main subject

prion protein family

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0 references

2

Neil R Cashman

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4 March 2020

author name string

Leslie I Grad

series ordinal

1

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4 March 2020

publication date

1 January 2014

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4 March 2020

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4 March 2020

volume

8

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4 March 2020

page(s)

33-41

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4 March 2020

issue

1

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

4 March 2020

cites work

1 reference

Amyotrophic lateral sclerosis: a review of current concepts.

21 January 2018

1 reference

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

1 reference

Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction.

21 January 2018

1 reference

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

1 reference

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p

21 January 2018

1 reference

Genetic factors in the early diagnosis of ALS.

21 January 2018

1 reference

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

21 January 2018

1 reference

Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis

21 January 2018

1 reference

Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis

21 January 2018

1 reference

New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes.

21 January 2018

1 reference

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

Superoxide dismutase: the cause of all amyotrophic lateral sclerosis?

21 January 2018

1 reference

Mutant superoxide dismutase-1 indistinguishable from wild-type causes ALS.

21 January 2018

1 reference

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

21 January 2018

1 reference

Role of SOD-1 and nitric oxide/cyclic GMP cascade on neurofilament aggregation in ALS/MND.

21 January 2018

1 reference

Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients

21 January 2018

1 reference

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

21 January 2018

1 reference

Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

21 January 2018

1 reference

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

1 reference

Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1.

21 January 2018

1 reference

Superoxide dismutase and the death of motoneurons in ALS.

21 January 2018

1 reference

Oxidation versus aggregation - how do SOD1 mutants cause ALS?

21 January 2018

1 reference

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: implication for protein aggregation and immune response.

21 January 2018

1 reference

Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice.

21 January 2018

1 reference

Focality of upper and lower motor neuron degeneration at the clinical onset of ALS.

21 January 2018

1 reference

ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration

21 January 2018

1 reference

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

21 January 2018

1 reference

Novel proteinaceous infectious particles cause scrapie

21 January 2018

1 reference

Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds.

21 January 2018

1 reference

Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis

21 January 2018

1 reference

Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.

21 January 2018

1 reference

Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site

21 January 2018

1 reference

Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis

21 January 2018

1 reference

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

21 January 2018

1 reference

Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mut

21 January 2018

1 reference

Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.

21 January 2018

1 reference

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

21 January 2018

1 reference

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

21 January 2018

1 reference

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

21 January 2018

1 reference

Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease

21 January 2018

1 reference

Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1 G86R.

21 January 2018

1 reference

Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme

21 January 2018

1 reference

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

21 January 2018

1 reference

Deadly conformations--protein misfolding in prion disease

21 January 2018

1 reference

Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1.

21 January 2018

1 reference

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

21 January 2018

1 reference

The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

1 reference

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

21 January 2018

1 reference

Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants

21 January 2018

1 reference

Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival

21 January 2018

1 reference

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

21 January 2018

1 reference

Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis

21 January 2018

1 reference

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

21 January 2018

1 reference

Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions

21 January 2018

1 reference

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

1 reference

Exosomes: from biogenesis and secretion to biological function

21 January 2018

1 reference

Localization of the Epstein-Barr virus protein LMP 1 to exosomes

21 January 2018

1 reference

The Trojan exosome hypothesis

21 January 2018

1 reference

Evidence That HIV Budding in Primary Macrophages Occurs through the Exosome Release Pathway

21 January 2018

1 reference

The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space

21 January 2018

1 reference

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

Cells release prions in association with exosomes

21 January 2018

1 reference

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

21 January 2018

1 reference

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis

21 January 2018

1 reference

Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis

21 January 2018

1 reference

Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis

21 January 2018

1 reference

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS.

21 January 2018

1 reference

Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis

21 January 2018

1 reference

Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?

21 January 2018

1 reference

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

21 January 2018

1 reference

Strain-specified characteristics of mouse synthetic prions

21 January 2018

1 reference

Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone

21 January 2018

1 reference

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

21 January 2018

1 reference

Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization.

21 January 2018

1 reference

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

21 January 2018

1 reference

Prion-like properties of pathological TDP-43 aggregates from diseased brains

21 January 2018

1 reference

50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes

21 January 2018

1 reference

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

ALS, SOD and peroxynitrite

21 January 2018

1 reference

EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles

21 January 2018

1 reference

12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

1 reference

12 December 2020

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1 reference

12 December 2020

Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice

1 reference

12 December 2020

Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase

1 reference

12 December 2020

Genetics of amyotrophic lateral sclerosis

1 reference

12 December 2020

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

1 reference

12 December 2020

Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy

1 reference

12 December 2020

Updates on amyotrophic lateral sclerosis: improving patient care

1 reference

12 December 2020

Identifiers

DOI

10.4161/PRI.27602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24394345%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

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4 March 2020

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