Apoptosis regulation at the mitochondrial outer membrane (Q38181031)

30 August 2017

Apoptosis regulation at the mitochondrial outer membrane (English)

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30 August 2017

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Laura A Gillies

1

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PubMed ID

24453042

30 August 2017

Tomomi Kuwana

series ordinal

2

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30 August 2017

1 April 2014

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Journal of Cellular Biochemistry

30 August 2017

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30 August 2017

115

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30 August 2017

632-640

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30 August 2017

4

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The Bcl-2 apoptotic switch in cancer development and therapy

30 August 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

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Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis

21 January 2018

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Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy.

21 January 2018

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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 January 2018

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Molecular details of Bax activation, oligomerization, and membrane insertion.

21 January 2018

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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization

21 January 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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21 January 2018

The BCL-2 family reunion

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Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

21 January 2018

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Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

21 January 2018

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Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

21 January 2018

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

21 January 2018

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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

21 January 2018

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Cell death: critical control points

21 January 2018

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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity

21 January 2018

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Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

21 January 2018

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Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

21 January 2018

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

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Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics

21 January 2018

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Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

21 January 2018

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To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

21 January 2018

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Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

21 January 2018

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

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BH3 domains other than Bim and Bid can directly activate Bax/Bak

21 January 2018

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The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment

21 January 2018

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Mechanisms and Functions of Cell Death

21 January 2018

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Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy.

21 January 2018

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The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

21 January 2018

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BAX activation is initiated at a novel interaction site

21 January 2018

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BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

21 January 2018

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A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

21 January 2018

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

21 January 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

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Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes

21 January 2018

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Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

21 January 2018

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Bcl-2-family proteins and the role of mitochondria in apoptosis

21 January 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process

21 January 2018

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Caspase-independent mitochondrial cell death results from loss of respiration, not cytotoxic protein release.

21 January 2018

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

21 January 2018

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Direct activation of full-length proapoptotic BAK

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

21 January 2018

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

21 January 2018

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Assembly of the mitochondrial apoptosis-induced channel, MAC.

21 January 2018

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

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The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

21 January 2018

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BID-induced structural changes in BAK promote apoptosis

21 January 2018

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Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

21 January 2018

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

21 January 2018

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Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

21 January 2018

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Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

21 January 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

21 January 2018

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Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

21 January 2018

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A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

21 January 2018

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

21 January 2018

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BAX-dependent transport of cytochrome c reconstituted in pure liposomes

21 January 2018

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Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

21 January 2018

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Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release

21 January 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

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Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

21 January 2018

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The mechanism of pore formation by bacterial toxins

21 January 2018

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Structural basis of pore formation by the bacterial toxin pneumolysin

21 January 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

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A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid.

21 January 2018

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

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A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

21 January 2018

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

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Can the analysis of BH3-only protein knockout mice clarify the issue of 'direct versus indirect' activation of Bax and Bak?

21 January 2018

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

21 January 2018

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Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

21 January 2018

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Different forms of cell death induced by putative BCL2 inhibitors.

21 January 2018

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Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death

21 January 2018

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Mitochondrial fusion and fission in cell life and death

21 January 2018

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Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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Three-dimensional structure of Bax-mediated pores in membrane bilayers

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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Mitochondrial fission, fusion, and stress

21 January 2018

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

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The role of ARK in stress-induced apoptosis in Drosophila cells

21 January 2018

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCB.24709

1 reference

30 August 2017

1 reference

PubMed ID

24453042