Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? (Q38189135)

30 August 2017

title

Targeting classical IL-6 signalling or IL-6 trans-signalling in depression? (English)

1 reference

30 August 2017

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

George Anderson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Marta Kubera

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Michael Maes

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

language of work or name

English

0 references

publication date

19 February 2014

1 reference

Expert Opinion on Therapeutic Targets

30 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

495-512

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24548241%20AND%20SRC:MED&resulttype=core&format=json

A review on the acute phase response in major depression

6 June 2020

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Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms.

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Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications

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Overnight Changes of Immune Parameters and Catecholamines Are Associated With Mood and Stress

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Lower CSF interleukin-6 predicts future depression in a population-based sample of older women followed for 17 years

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Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression

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A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis

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The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes

21 January 2018

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IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice

21 January 2018

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Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury

21 January 2018

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Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression

21 January 2018

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Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression

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Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

21 January 2018

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21 January 2018

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The inflammatory response following delivery is amplified in women who previously suffered from major depression, suggesting that major depression is accompanied by a sensitization of the inflammatory response system

21 January 2018

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So depression is an inflammatory disease, but where does the inflammation come from?

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In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression

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21 January 2018

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Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation

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21 January 2018

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Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.

21 January 2018

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IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors

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Constant darkness induces IL-6-dependent depression-like behavior through the NF-κB signaling pathway.

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IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions

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Antidepressants and neuroinflammation: Can antidepressants calm glial rage down?

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Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder

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Effects of repeated fluoxetine and citalopram administration on cytokine release in C57BL/6 mice

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Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice

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Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells.

21 January 2018

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Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6.

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Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells

21 January 2018

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The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products

21 January 2018

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Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine

21 January 2018

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Dopamine agonists upregulate IL-6 and IL-8 production in human keratinocytes

21 January 2018

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Leptin and interleukin-6 alter the function of mesolimbic dopamine neurons in a rodent model of prenatal inflammation

21 January 2018

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Does dopamine dysfunction drive depression?

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New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

21 January 2018

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Passage of cytokines across the blood-brain barrier

21 January 2018

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Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits

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IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

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21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Biologic therapy for autoimmune diseases: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Tocilizumab: a novel humanized anti-interleukin 6 (IL-6) receptor antibody for the treatment of patients with non-RA systemic, inflammatory rheumatic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Tocilizumab treatment decreases circulating myeloid dendritic cells and monocytes, 2 components of the myeloid lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Serum level of oxidative stress marker is dramatically low in patients with rheumatoid arthritis treated with tocilizumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Hitting a complex target: an update on interleukin-6 trans-signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Targeting IL-1 in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417

Acute phase proteins in major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2014.888417