The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. (Q38191251)

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8 March 2020

review article

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title

The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options (English)

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8 March 2020

2

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8 March 2020

Burcin Ekser

series ordinal

3

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4

David K C Cooper

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8 March 2020

1

Hayato Iwase

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8 March 2020

publication date

27 February 2014

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8 March 2020

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volume

21

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issue

3

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8 March 2020

page(s)

201-220

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Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here?

8 March 2020

cites work

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Intravenous infusion of Galalpha1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts

21 January 2018

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The influence of antibody and complement removal with a Ig-Therasorb column in a xenogeneic working heart model

21 January 2018

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Improvement in human decay accelerating factor transgenic porcine kidney xenograft rejection with intravenous administration of gas914, a polymeric form of alphaGAL.

21 January 2018

1 reference

alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months

21 January 2018

1 reference

Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

21 January 2018

1 reference

Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons

21 January 2018

1 reference

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients

21 January 2018

1 reference

Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons

21 January 2018

1 reference

B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

21 January 2018

1 reference

Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts

21 January 2018

1 reference

Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function

21 January 2018

1 reference

Intravascular thrombosis in discordant xenotransplantation.

21 January 2018

1 reference

Coagulation and the xenograft endothelium

21 January 2018

1 reference

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies.

21 January 2018

1 reference

The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them.

21 January 2018

1 reference

Coagulation dysregulation as a barrier to xenotransplantation in the primate

21 January 2018

1 reference

Controlling coagulation dysregulation in xenotransplantation

21 January 2018

1 reference

Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells

21 January 2018

1 reference

Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation.

21 January 2018

1 reference

Disordered regulation of coagulation and platelet activation in xenotransplantation

21 January 2018

1 reference

Coagulation, platelet activation and thrombosis in xenotransplantation

21 January 2018

1 reference

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation

21 January 2018

1 reference

Scientific and therapeutic advances in antiplatelet therapy

21 January 2018

1 reference

Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium

21 January 2018

1 reference

Which anti-platelet therapies might be beneficial in xenotransplantation?

21 January 2018

1 reference

Endothelial cell activation and thromboregulation during xenograft rejection

21 January 2018

1 reference

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

21 January 2018

1 reference

Platelet-mediated activation of endothelial cells: implications for the pathogenesis of transplant rejection.

21 January 2018

1 reference

Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets.

21 January 2018

1 reference

Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection

21 January 2018

1 reference

Mechanisms of thrombus formation

21 January 2018

1 reference

Expression of tissue factor mRNA in cardiac xenografts: clues to the pathogenesis of acute vascular rejection

21 January 2018

1 reference

Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein

21 January 2018

1 reference

The Kunitz-3 domain of TFPI-alpha is required for protein S-dependent enhancement of factor Xa inhibition

21 January 2018

1 reference

The anticoagulant protein C pathway

21 January 2018

1 reference

Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection

21 January 2018

1 reference

Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.

21 January 2018

1 reference

Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons

21 January 2018

1 reference

The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors

21 January 2018

1 reference

Interaction of porcine von Willebrand factor with the platelet glycoproteins Ib and IIb/IIIa complex

21 January 2018

1 reference

Evaluation of platelet function under high shear condition in the small-sized collagen bead column

21 January 2018

1 reference

Immune complex formation after xenotransplantation : evidence of type III as well as type II immune reactions provide clues to pathophysiology

21 January 2018

1 reference

Assay and characterization of the factor in porcine and bovine plasma which aggregates human platelets

21 January 2018

1 reference

Shear-induced platelet aggregation

21 January 2018

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Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets

21 January 2018

1 reference

O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors

21 January 2018

1 reference

Central role of the P2Y12 receptor in platelet activation

21 January 2018

1 reference

Platelet integrin alpha(IIb)beta(3): activation mechanisms

21 January 2018

1 reference

Loss of ATP diphosphohydrolase activity with endothelial cell activation

21 January 2018

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Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection

21 January 2018

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Activation of coagulation factor V by a platelet protease

21 January 2018

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Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity

21 January 2018

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The growing complexity of platelet aggregation

21 January 2018

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Inhibitors of platelet adhesion

21 January 2018

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Extracellular ATP and ADP activate transcription factor NF-kappa B and induce endothelial cell apoptosis

21 January 2018

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Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.

21 January 2018

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Polyphosphate enhances fibrin clot structure

21 January 2018

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Platelet-mediated enhancement of leukocyte adhesion

21 January 2018

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Platelets an inflammatory force in transplantation

21 January 2018

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Platelets: signaling cells in the immune continuum.

21 January 2018

1 reference

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis

21 January 2018

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The vessel wall and its interactions

21 January 2018

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Platelets deliver costimulatory signals to antigen-presenting cells: a potential bridge between injury and immune activation

21 January 2018

1 reference

CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets.

21 January 2018

1 reference

Platelets influence vascularized organ transplants from start to finish

21 January 2018

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P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface.

21 January 2018

1 reference

Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production

21 January 2018

1 reference

Cytokine mRNA expression in human platelets and a megakaryocytic cell line and cytokine modulation of platelet function

21 January 2018

1 reference

Understanding and evaluating platelet function

21 January 2018

1 reference

Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

21 January 2018

1 reference

Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells

21 January 2018

1 reference

Aggregation of human platelets in plasma by porcine blood cells in vitro is probably mediated by thrombin generation

21 January 2018

1 reference

Mechanisms of xenogeneic baboon platelet aggregation and phagocytosis by porcine liver sinusoidal endothelial cells

21 January 2018

1 reference

Platelet aggregation in humans and nonhuman primates: relevance to xenotransplantation.

21 January 2018

1 reference

Production of alpha 1,3-galactosyltransferase-deficient pigs

21 January 2018

1 reference

Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen

21 January 2018

1 reference

First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation

21 January 2018

1 reference

Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation

21 January 2018

1 reference

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

21 January 2018

1 reference

Pathology of renal xenograft rejection in pig to non-human primate transplantation

21 January 2018

1 reference

Results of gal-knockout porcine thymokidney xenografts

21 January 2018

1 reference

Pig-to-baboon liver xenografts

21 January 2018

1 reference

Discordant organ xenotransplantation in primates: world experience and current status

21 January 2018

1 reference

Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance

21 January 2018

1 reference

Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons

21 January 2018

1 reference

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

21 January 2018

1 reference

Primary porcine Kupffer cell phagocytosis of human platelets involves the CD18 receptor

21 January 2018

1 reference

Thrombocytopenia after pig-to-baboon liver xenotransplantation: where do platelets go?

21 January 2018

1 reference

Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes

21 January 2018

1 reference

Clinical islet xenotransplantation: how close are we?

21 January 2018

1 reference

Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation

21 January 2018

1 reference

Bidirectional relation between inflammation and coagulation

21 January 2018

1 reference

Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.

21 January 2018

1 reference

Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates

21 January 2018

1 reference

Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nonGal IgG binding to porcine aortic endothelial cells

21 January 2018

1 reference

Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum

21 January 2018

1 reference

Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation?

21 January 2018

1 reference

Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans

21 January 2018

1 reference

Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models.

21 January 2018

1 reference

Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs

21 January 2018

1 reference

Xenoantigens and xenoantibodies

21 January 2018

1 reference

Carbohydrates in xenotransplantation.

21 January 2018

1 reference

Identification of new carbohydrate and membrane protein antigens in cardiac xenotransplantation

21 January 2018

1 reference

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

21 January 2018

1 reference

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation

21 January 2018

1 reference

Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis.

21 January 2018

1 reference

Regulated inhibition of coagulation by porcine endothelial cells expressing P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins

21 January 2018

1 reference

Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

21 January 2018

1 reference

Recombinant pig TFPI efficiently regulates human tissue factor pathways

21 January 2018

1 reference

The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways

21 January 2018

1 reference

Inflammation and the activated protein C anticoagulant pathway

21 January 2018

1 reference

The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis.

21 January 2018

1 reference

Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model

21 January 2018

1 reference

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

21 January 2018

1 reference

Expression of human thrombomodulin cofactor activity in porcine endothelial cells

21 January 2018

1 reference

Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice

21 January 2018

1 reference

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

21 January 2018

1 reference

21 January 2018

The Protein C Pathway

1 reference

The endothelial protein C receptor

21 January 2018

1 reference

The discovery of the endothelial cell protein C receptor

21 January 2018

1 reference

Protective effects of transgenic human endothelial protein C receptor expression in murine models of transplantation.

21 January 2018

1 reference

Factors in xenograft rejection

21 January 2018

1 reference

Loss of ecto-5'nucleotidase from porcine endothelial cells after exposure to human blood: Implications for xenotransplantation

21 January 2018

1 reference

Platelet activation and atherothrombosis

21 January 2018

1 reference

Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury

21 January 2018

1 reference

Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis

21 January 2018

1 reference

Low-molecular-weight heparins

21 January 2018

1 reference

Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation

21 January 2018

1 reference

Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation

21 January 2018

1 reference

Heparin inhibition of von Willebrand factor-dependent platelet function in vitro and in vivo

21 January 2018

1 reference

Heparin and low molecular weight heparin but not hirudin stimulate platelet aggregation in whole blood from acetylsalicylic acid treated healthy volunteers

21 January 2018

1 reference

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

21 January 2018

1 reference

Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin

21 January 2018

1 reference

Soluble thrombomodulin protects ischemic kidneys

21 January 2018

1 reference

Thrombomodulin improves early outcomes after intraportal islet transplantation

21 January 2018

1 reference

Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

1 reference

Tissue factor pathway inhibitor and antithrombin trial results

21 January 2018

1 reference

Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies

21 January 2018

1 reference

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

21 January 2018

1 reference

Lovastatin enhances ecto-5'-nucleotidase activity and cell surface expression in endothelial cells: implication of rho-family GTPases

21 January 2018

1 reference

Low molecular weight dextran sulfate prevents complement activation and delays hyperacute rejection in pig-to-human xenotransplantation models

21 January 2018

1 reference

Endothelial cell protection by dextran sulfate: a novel strategy to prevent acute vascular rejection in xenotransplantation.

21 January 2018

1 reference

Low molecular weight dextran sulfate prevents the instant blood-mediated inflammatory reaction induced by adult porcine islets

21 January 2018

1 reference

Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.

21 January 2018

1 reference

Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice

21 January 2018

1 reference

Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates.

21 January 2018

1 reference

Anti-human von willebrand factor monoclonal antibody AJvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs.

21 January 2018

1 reference

Hyperacute lung rejection in the pig-to-human model. III. platelet receptor inhibitors synergistically modulate complement activation and lung injury

21 January 2018

1 reference

Aurintricarboxylic acid inhibits endothelial activation, complement activation, and von Willebrand factor secretion in vitro and attenuates hyperacute rejection in an ex vivo model of pig-to-human pulmonary xenotransplantation

21 January 2018

1 reference

Pre-treatment of porcine pulmonary xenograft with desmopressin: a novel strategy to attenuate platelet activation and systemic intravascular coagulation in an ex-vivo model of swine-to-human pulmonary xenotransplantation

21 January 2018

1 reference

TMVA, a novel GPIb-binding protein, significantly prevents platelet microthrombi formation and prolongs discordant cardiac xenograft survival

21 January 2018

1 reference

Platelet-directed therapies and coronary artery bypass grafting

21 January 2018

1 reference

Effective antiplatelet therapy does not prolong transgenic pig to baboon cardiac xenograft survival

21 January 2018

1 reference

Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival

21 January 2018

1 reference

Recurrence of acute myocardial infarction in patients discharged on clopidogrel and a proton pump inhibitor after stent placement for acute myocardial infarction.

21 January 2018

1 reference

Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel

21 January 2018

1 reference

Effects of SolCD39, a novel inhibitor of Platelet Aggregation, on Platelet Deposition and Aggregation after PTCA in a Porcine Model

21 January 2018

1 reference

Reduced fibrin deposition and intravascular thrombosis in hDAF transgenic pig hearts perfused with tirofiban

21 January 2018

1 reference

Low-dose aspirin for the prevention of atherothrombosis

21 January 2018

1 reference

GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism

21 January 2018

1 reference

Platelet-leukocyte aggregates and derived microparticles in inflammation, vascular remodelling and thrombosis

21 January 2018

1 reference

Reference values for thromboelastometry (ROTEM®) in cynomolgus monkeys (Macaca fascicularis).

21 January 2018

1 reference

Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation.

21 January 2018

1 reference

Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model

21 January 2018

1 reference

Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection

21 January 2018

1 reference

Effects of Long-term Administration of High-dose Recombinant Human Antithrombin in Immunosuppressed Primate Recipients of Porcine Xenografts

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/XEN.12085

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24571124%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

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