AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease (Q38196694)

30 August 2017

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title

AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease (English)

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30 August 2017

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cardiovascular disease

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Gregory R Steinberg

1

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PubMed ID

24638063

30 August 2017

Jonathan D Schertzer

series ordinal

2

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30 August 2017

18 March 2014

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Immunology & Cell Biology

30 August 2017

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30 August 2017

92

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30 August 2017

4

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30 August 2017

340-345

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Diabetes mellitus, fasting glucose, and risk of cause-specific death

30 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Immunological aspects of atherosclerosis: Figure 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Innate immune activation in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Adipose tissue as an endocrine organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Role and function of macrophages in the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Macrophages, inflammation, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Circulating mononuclear cells in the obese are in a proinflammatory state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The phenotype of infiltrating macrophages influences arteriosclerotic plaque vulnerability in the carotid artery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Inflammation in obesity is the common link between defects in fatty acid metabolism and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

New insights into ER stress-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The NLRP3 inflammasome: a sensor for metabolic danger?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Chronic TNF-α neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Effect of etanercept on insulin secretion and insulin sensitivity in a randomized trial with psoriatic patients at risk for developing type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPK in Health and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMP-activated protein kinase: a target for drugs both ancient and modern

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Immunometabolism of AMPK in insulin resistance and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Bioenergetic profiles diverge during macrophage polarization: implications for the interpretation of 18F-FDG PET imaging of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPK: mediating the metabolic effects of salicylate-based drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

How metabolism generates signals during innate immunity and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Fueling immunity: insights into metabolism and lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Metabolism of inflammation limited by AMPK and pseudo-starvation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Different effects of adiponectin isoforms in human monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The ancient drug salicylate directly activates AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Improvement of ER stress-induced diabetes by stimulating autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

Macrophage autophagy in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

p38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

T-ing up inflammation in fat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

7 January 2021

Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

7 January 2021

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

7 January 2021

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.11

7 January 2021

Identifiers

DOI

10.1038/ICB.2014.11

1 reference

30 August 2017

1 reference

PubMed ID

24638063