Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes (Q38209287)

31 August 2017

Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes (English)

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31 August 2017

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5

Assaf Rudich

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31 August 2017

4

Mihai Netea

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31 August 2017

Rinke Stienstra

1

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31 August 2017

Yulia Haim

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2

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31 August 2017

Yael Riahi

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3

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31 August 2017

Gil Leibowitz

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31 August 2017

5 May 2014

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31 August 2017

12

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inferred from page(s)

published in

Diabetologia

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31 August 2017

57

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31 August 2017

1505-1516

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31 August 2017

8

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https://scigraph.springernature.com/pub.10.1007/s00125-014-3255-3

31 August 2017

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Autophagy in adipose tissue biology

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Autophagy is involved in adipogenic differentiation by repressesing proteasome-dependent PPARγ2 degradation

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Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

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The relationship between metabolism and the autophagy machinery during the innate immune response

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Metabolic endotoxaemia: is it more than just a gut feeling?

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

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Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation

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Modulation of inflammation by autophagy: consequences for Crohn's disease.

21 January 2018

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The inflammasome puts obesity in the danger zone

21 January 2018

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Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

21 January 2018

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Metabolism of inflammation limited by AMPK and pseudo-starvation

21 January 2018

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5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.

21 January 2018

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ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease

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Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate.

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Defective regulation of adipose tissue autophagy in obesity.

21 January 2018

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Autophagy regulates inflammation in adipocytes.

21 January 2018

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Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

21 January 2018

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Orchestrating the unfolded protein response in health and disease

21 January 2018

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Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

21 January 2018

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Hypothalamic dysfunction in obesity

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

21 January 2018

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Inflammation of the hypothalamus leads to defective pancreatic islet function.

21 January 2018

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Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway

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21 January 2018

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Islet beta cell failure in type 2 diabetes

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21 January 2018

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Autophagy and the integrated stress response

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Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell

21 January 2018

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Resistance of the insulin crystal to lysosomal proteases: implications for pancreatic B-cell crinophagy.

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

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Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation

21 January 2018

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Morphologic effects of diazoxide and diphenylhydantoin on insulin secretion and biosynthesis in B cells of mice

21 January 2018

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Munc 18-1 and granuphilin collaborate during insulin granule exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

SNARE proteins are required for macroautophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

21 January 2018

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Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Autophagy in human type 2 diabetes pancreatic beta cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Fatty acids suppress autophagic turnover in β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets

21 January 2018

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Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line

21 January 2018

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

21 January 2018

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mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

21 January 2018

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Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

21 January 2018

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Autophagy is activated for cell survival after endoplasmic reticulum stress

21 January 2018

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Proinsulin maturation, misfolding, and proteotoxicity

21 January 2018

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Misfolded proinsulin affects bystander proinsulin in neonatal diabetes

21 January 2018

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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

21 January 2018

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Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

21 January 2018

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Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

21 January 2018

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Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation

21 January 2018

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Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans

21 January 2018

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Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-014-3255-3

Identification of a candidate therapeutic autophagy-inducing peptide

21 January 2018

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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?

21 January 2018

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12 December 2020

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

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12 December 2020

Autophagy regulates adipose mass and differentiation in mice

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12 December 2020

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

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12 December 2020

Altered autophagy in human adipose tissues in obesity

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12 December 2020

Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue

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12 December 2020

Autophagy in adipose tissue

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12 December 2020

Role of rapamycin-induced autophagy in pancreatic islets

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12 December 2020

Mode of action of chloroquine in patients with non-insulin-dependent diabetes mellitus

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12 December 2020

The end of autophagic cell death?

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12 December 2020

Mechanism and regulation of protein degradation in liver

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12 December 2020

Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes

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12 December 2020

LAMP-2: a control step for phagosome and autophagosome maturation

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12 December 2020

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content

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12 December 2020

Rosiglitazone protects against palmitate-induced pancreatic beta-cell death by activation of autophagy via 5'-AMP-activated protein kinase modulation

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12 December 2020

Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression

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12 December 2020

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells

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12 December 2020

Lysosomes and pancreatic islet function. Time course of insulin biosynthesis, insulin secretion, and lysosomal transformation after rapid changes in glucose concentration

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12 December 2020

10.1007/S00125-014-3255-3

Identifiers

DOI

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Dimensions Publication ID

31 August 2017

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