Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine (Q63609769)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23202295%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine (English)

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19 February 2020

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16

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19 February 2020

author name string

Kook Hwan Kim

1

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19 February 2020

Yeon Taek Jeong

2

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19 February 2020

Hyunhee Oh

3

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19 February 2020

Seong Hun Kim

4

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19 February 2020

Jae Min Cho

5

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19 February 2020

Yo-Na Kim

6

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19 February 2020

Su Sung Kim

7

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19 February 2020

Do Hoon Kim

8

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19 February 2020

Kyu Yeon Hur

9

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19 February 2020

Hyoung Kyu Kim

10

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19 February 2020

TaeHee Ko

11

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19 February 2020

Jin Han

12

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19 February 2020

Hong Lim Kim

13

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19 February 2020

Jin Kim

14

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19 February 2020

Sung Hoon Back

15

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19 February 2020

Hsiuchen Chen

17

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19 February 2020

David C Chan

18

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19 February 2020

Morichika Konishi

19

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19 February 2020

Nobuyuki Itoh

20

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19 February 2020

Cheol Soo Choi

21

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19 February 2020

Myung-Shik Lee

22

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19 February 2020

language of work or name

English

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publication date

2 December 2012

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19 February 2020

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19 February 2020

volume

19

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19 February 2020

issue

1

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19 February 2020

page(s)

83-92

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https://scigraph.springernature.com/pub.10.1038/nm.3014

19 February 2020

exact match

0 references

cites work

The cell-non-autonomous nature of electron transport chain-mediated longevity

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12 December 2020

Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

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Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

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Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance

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A guide to analysis of mouse energy metabolism

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Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

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FGF21 is an Akt-regulated myokine

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Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

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Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans

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12 December 2020

Weight-reducing effects of the plasma protein encoded by the obese gene

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12 December 2020

Autophagy regulates adipose mass and differentiation in mice

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12 December 2020

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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12 December 2020

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

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12 December 2020

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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12 December 2020

The role of thyroid hormones in the control of energy expenditure

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12 December 2020

Autophagy regulates lipid metabolism

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12 December 2020

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

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12 December 2020

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

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12 December 2020

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

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12 December 2020

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

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12 December 2020

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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12 December 2020

Mitochondrial myopathy induces a starvation-like response

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12 December 2020

The MAP1-LC3 conjugation system is involved in lipid droplet formation

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12 December 2020

Autophagy is required to maintain muscle mass.

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12 December 2020

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

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12 December 2020

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

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12 December 2020

Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

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12 December 2020

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

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12 December 2020

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

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12 December 2020

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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12 December 2020

Tissue-specific functions in the fatty acid-binding protein family

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12 December 2020

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

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12 December 2020

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

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12 December 2020

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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12 December 2020

Fibroblast growth factor 21 corrects obesity in mice

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12 December 2020

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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12 December 2020

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

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12 December 2020

Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin

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12 December 2020

Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes

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12 December 2020

Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB).

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12 December 2020

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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12 December 2020

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

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12 December 2020

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

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12 December 2020

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

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12 December 2020

Selective expression of Cre recombinase in skeletal muscle fibers

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12 December 2020

Altered lipid content inhibits autophagic vesicular fusion

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12 December 2020

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

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12 December 2020

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

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12 December 2020

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

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12 December 2020

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

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12 December 2020

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

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12 December 2020

Autophagy in the Pathogenesis of Disease

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12 December 2020

FGF-21 as a novel metabolic regulator

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12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

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12 December 2020

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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12 December 2020

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response

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12 December 2020

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

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12 December 2020

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study.

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12 December 2020

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo

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12 December 2020

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3014

7 January 2021

inferred from DOI database lookup

Selective expression of Cre recombinase in skeletal muscle fibers

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3014

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23202295%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 February 2020

0 references

1 reference