Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy. (Q38225316)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24984804%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy (English)

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21 March 2020

3

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21 March 2020

author name string

Silvia Peppicelli

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24984804%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

Francesca Bianchini

series ordinal

2

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21 March 2020

publication date

1 September 2014

1 reference

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Cancer and Metastasis Reviews

21 March 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24984804%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

volume

33

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21 March 2020

issue

2-3

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21 March 2020

page(s)

823-832

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Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity.

21 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cellular interactions in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Tumor-microenvironment interactions: dangerous liaisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Metastasis: from dissemination to organ-specific colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Microenvironmental regulation of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Models, mechanisms and clinical evidence for cancer dormancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Contact interactions between cells that suppress neoplastic development: can they also explain metastatic dormancy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Lymphangiogenesis: Molecular mechanisms and future promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

History of the Pasteur effect and its pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hypoxia, HIF1 and glucose metabolism in the solid tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Is cancer a disease of abnormal cellular metabolism? New angles on an old idea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Lactate: a metabolic key player in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

21 January 2018

Cancer cell metabolism.

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cell-cell and intracellular lactate shuttles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Lactate metabolism: a new paradigm for the third millennium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Disrupting proton dynamics and energy metabolism for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Clastogenicity of low pH to various cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Dysregulated pH: a perfect storm for cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hypoxia signalling in cancer and approaches to enforce tumour regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cell migration: integrating signals from front to back

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acid-Induced Equilibrium Folding Intermediate of Human Platelet Profilin†

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Protons extruded by NHE1: digestive or glue?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acidic extracellular pH promotes activation of integrin α(v)β(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

pH regulators in invadosomal functioning: proton delivery for matrix tasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Novel invadopodia components revealed by differential proteomic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Alterations in proteolytic activity at low pH and its association with invasion: a theoretical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The urokinase receptor: involvement in cell surface proteolysis and cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Human heparanase. Purification, characterization, cloning, and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Epithelial-mesenchymal transition and its implications for fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

EMT: when epithelial cells decide to become mesenchymal-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Low extracellular pH induces activation of ERK 2, JNK, and p38 in A431 and Swiss 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acid increases MAPK-mediated proliferation in Barrett's esophageal adenocarcinoma cells via intracellular acidification through a Cl-/HCO3- exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acidic pre-conditioning suppresses apoptosis and increases expression of Bcl-xL in coronary endothelial cells under simulated ischaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Protein turnover via autophagy: implications for metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Acidic stress promotes a glioma stem cell phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Lactate stimulates endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The genomic analysis of lactic acidosis and acidosis response in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

pH and drug resistance in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Effects of agents which inhibit the regulation of intracellular pH on murine solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Effect of pH on radiation-induced p53 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Influence of environmental pH on G2-phase arrest caused by ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Tumor pH and its measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

A novel technology for the imaging of acidic prostate tumors by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Bicarbonate increases tumor pH and inhibits spontaneous metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Reduction of metastasis using a non-volatile buffer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Targeting vacuolar H+-ATPases as a new strategy against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Biological effects of a new vacuolar-H,-ATPase inhibitor in colon carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Urokinase plasminogen activator receptor induced non-small cell lung cancer invasion and metastasis requires NHE1 transporter expression and transport activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Plasmalemmal vacuolar-type H+-ATPase in cancer biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-014-9506-4

Retraction: Blockage of intracellular proton extrusion with proton pump inhibitor induces apoptosis in gastric cancer.

21 January 2018

1 reference

3 January 2024

https://opencitations.net/index/api/v1/citations/10.1111/J.1349-7006.2007.00642.X

Identifiers

DOI

10.1007/S10555-014-9506-4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24984804%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

21 March 2020

1039989046

0 references

1 reference

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