Hypoxia signalling in cancer and approaches to enforce tumour regression (Q36488739)

14 August 2017

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title

Hypoxia signalling in cancer and approaches to enforce tumour regression (English)

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14 August 2017

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1

Jacques Pouysségur

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14 August 2017

Frédéric Dayan

2

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PubMed ID

16724055

14 August 2017

Nathalie M Mazure

series ordinal

3

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PubMed ID

16724055

14 August 2017

language of work or name

English

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publication date

1 May 2006

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14 August 2017

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14 August 2017

441

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14 August 2017

7092

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14 August 2017

437-443

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https://scigraph.springernature.com/pub.10.1038/nature04871

14 August 2017

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cites work

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

How do small GTPase signal transduction pathways regulate cell cycle entry?

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Ras GTPases: integrins' friends or foes?

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

MAP kinases and hypoxia in the control of VEGF expression

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Purification and characterization of hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The biology of VEGF and its receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Blood vessels and nerves: common signals, pathways and diseases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Signalling via the hypoxia-inducible factor-1alpha requires multiple posttranslational modifications

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https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Activation of the HIF pathway in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

BNip3 and signal-specific programmed death in the heart

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

An expanding role for mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

New roles for the LKB1-->AMPK pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-inducible factors and hypoxic cell death in tumour physiology

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Bcl-2/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Role of VHL gene mutation in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Epithelial-mesenchymal transitions in development and pathologies

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Investigating hypoxic tumor physiology through gene expression patterns

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Angiogenesis as a therapeutic target

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The SLC4 family of HCO 3 - transporters

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The expanding family of eucaryotic Na(+)/H(+) exchangers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Monocarboxylate transporter MCT1 is a target for immunosuppression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Autophagy in metazoans: cell survival in the land of plenty

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The role of autophagy in cancer development and response to therapy.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

The role of hypoxia-induced factors in tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia-responsive transcription factors.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Hypoxia requires notch signaling to maintain the undifferentiated cell state

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04871

7 January 2021

Identifiers

DOI

10.1038/NATURE04871

1 reference

14 August 2017

1 reference

PubMed ID

16724055