Dysregulated pH: a perfect storm for cancer progression. (Q45255109)

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10 February 2020

review article

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title

Dysregulated pH: a perfect storm for cancer progression (English)

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10 February 2020

3

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10 February 2020

Bradley A Webb

series ordinal

1

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10 February 2020

4

Diane L Barber

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10 February 2020

author name string

Michael Chimenti

series ordinal

2

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10 February 2020

language of work or name

English

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publication date

11 August 2011

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10 February 2020

published in

Nature Reviews Cancer

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10 February 2020

volume

11

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10 February 2020

issue

9

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10 February 2020

page(s)

671-677

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https://scigraph.springernature.com/pub.10.1038/nrc3110

10 February 2020

exact match

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cites work

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pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution

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NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

31 March 2020

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Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

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Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells

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Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity

31 March 2020

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Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells

31 March 2020

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Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes

31 March 2020

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Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo

31 March 2020

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Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin

31 March 2020

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EGF upregulates Na+/H+ exchanger NHE1 by post-translational regulation that is important for cervical cancer cell invasiveness

31 March 2020

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Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma.

31 March 2020

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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.

31 March 2020

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Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44

31 March 2020

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Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

31 March 2020

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The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

31 March 2020

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Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells

31 March 2020

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

31 March 2020

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A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis

31 March 2020

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The spatial organization of proton and lactate transport in a rat brain tumor

31 March 2020

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Intracellular pH gradients in migrating cells

31 March 2020

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The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths

31 March 2020

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Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

31 March 2020

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High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer

31 March 2020

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The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

31 March 2020

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Acid-mediated tumor invasion: a multidisciplinary study

31 March 2020

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Protons make tumor cells move like clockwork

31 March 2020

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Intracellular pH sensors: design principles and functional significance

31 March 2020

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Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblasts

31 March 2020

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Effects of growth factors on intracellular pH regulation

31 March 2020

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A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages

31 March 2020

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Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation

31 March 2020

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Alterations of intracellular pH homeostasis in apoptosis: origins and roles

31 March 2020

1 reference

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

31 March 2020

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Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

31 March 2020

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Metaphase I arrest of starfish oocytes induced via the MAP kinase pathway is released by an increase of intracellular pH.

31 March 2020

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Intracellular acidification delays hormonal G2/M transition and inhibits G2/M transition triggered by thiophosphorylated MAPK in Xenopus oocytes

31 March 2020

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Cell cycle progression and apoptosis after irradiation in an acidic environment

31 March 2020

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DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

31 March 2020

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Genomic screening in vivo reveals the role played by vacuolar H+ ATPase and cytosolic acidification in sensitivity to DNA-damaging agents such as cisplatin

31 March 2020

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

31 March 2020

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Why do cancers have high aerobic glycolysis?

31 March 2020

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Targeting metabolic transformation for cancer therapy.

31 March 2020

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Tumor cell metabolism: cancer's Achilles' heel

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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The role of cell swelling in the stimulation of glycogen synthesis by insulin

31 March 2020

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Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

31 March 2020

1 reference

Kinetics of enamel dissolution during formation of incipient caries-like lesions

31 March 2020

1 reference

Regulation of muscle phosphofructokinase by physiological concentrations of bisphosphorylated hexoses: effect of alkalinization

31 March 2020

1 reference

The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle

31 March 2020

1 reference

Purification and properties of pyruvate kinase type M2 from rat lung

31 March 2020

1 reference

Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme

31 March 2020

1 reference

Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

1 reference

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

31 March 2020

1 reference

Brick by brick: metabolism and tumor cell growth

31 March 2020

1 reference

Expression profile of genes regulated by activity of the Na-H exchanger NHE1

31 March 2020

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The genomic analysis of lactic acidosis and acidosis response in human cancers

31 March 2020

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Novel invadopodia components revealed by differential proteomic analysis.

31 March 2020

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Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane

31 March 2020

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Mapping of glycolytic enzyme-binding sites on human erythrocyte band 3.

31 March 2020

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Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity

31 March 2020

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Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells

31 March 2020

1 reference

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

31 March 2020

1 reference

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

31 March 2020

1 reference

Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor

31 March 2020

1 reference

Acid-Induced Equilibrium Folding Intermediate of Human Platelet Profilin†

31 March 2020

1 reference

Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo

31 March 2020

1 reference

Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain

31 March 2020

1 reference

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

31 March 2020

1 reference

Characterization of an Actin-binding Site within the Talin FERM Domain

31 March 2020

1 reference

The effect of intact talin and talin tail fragment on actin filament dynamics and structure depends on pH and ionic strength

31 March 2020

1 reference

Interaction of talin with actin: sensitive modulation of filament crosslinking activity

31 March 2020

1 reference

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells

31 March 2020

1 reference

A common cofilin activity cycle in invasive tumor cells and inflammatory cells

31 March 2020

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Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

31 March 2020

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Lipid signalling in disease.

31 March 2020

1 reference

Protons extruded by NHE1: digestive or glue?

31 March 2020

1 reference

Migration of human melanoma cells depends on extracellular pH and Na+/H+ exchange

31 March 2020

1 reference

Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation

31 March 2020

1 reference

Acidic extracellular pH promotes activation of integrin α(v)β(3).

31 March 2020

1 reference

Tumour-stromal interactions in acid-mediated invasion: a mathematical model

31 March 2020

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Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.

31 March 2020

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Non-equilibration of hydrostatic pressure in blebbing cells.

31 March 2020

1 reference

A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition

31 March 2020

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CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

31 March 2020

1 reference

Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles

31 March 2020

1 reference

Bicarbonate increases tumor pH and inhibits spontaneous metastases

31 March 2020

1 reference

Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics

31 March 2020

1 reference

Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro

31 March 2020

1 reference

Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents

31 March 2020

1 reference

Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs

31 March 2020

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P-glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine

31 March 2020

1 reference

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

31 March 2020

1 reference

The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models

31 March 2020

1 reference

A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery.

31 March 2020

1 reference

Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation.

31 March 2020

1 reference

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

31 March 2020

1 reference

Design of Environment‐Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

31 March 2020

1 reference

Diverse somatic mutation patterns and pathway alterations in human cancers

31 March 2020

1 reference

A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

31 March 2020

1 reference

Crippling p53 activities via knock-in mutations in mouse models

31 March 2020

1 reference

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

31 March 2020

1 reference

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

31 March 2020

1 reference

12 December 2020

The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature

1 reference

12 December 2020

Tumor-associated carbonic anhydrases and their clinical significance.

1 reference

12 December 2020

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

1 reference

12 December 2020

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells

1 reference

12 December 2020

Enzymatic regulation of glycolysis and gluconeogenesis in rabbit periodontal ligament under various physiological pH conditions

1 reference

12 December 2020

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

1 reference

12 December 2020

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

1 reference

12 December 2020

Effect of pH on the kinetics of frog muscle phosphofructokinase

1 reference

12 December 2020

pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

1 reference

12 December 2020

Phosphofructokinase. III. Correlation of the regulatory kinetic and molecular properties of the rabbit muscle enzyme

1 reference

12 December 2020

Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21833026%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 February 2020

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