The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters (Q38230038)

31 August 2017

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters (English)

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31 August 2017

Jinwei Zhang

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Dario Alessi

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Dario R Alessi

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author name string

Arjun Khanna

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31 August 2017

Thomas Hochdörfer

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31 August 2017

Yuze Shang

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31 August 2017

Kristopher T Kahle

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15 July 2014

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re3

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Targeting cancer with small molecule kinase inhibitors

31 August 2017

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Kinase drug discovery--what's next in the field?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The SLC12 family of electroneutral cation-coupled chloride cotransporters.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Roles of the cation-chloride cotransporters in neurological disease.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

A thermodynamic study of electroneutral K-Cl cotransport in pH- and volume-clamped low K sheep erythrocytes with normal and low internal magnesium

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Functional evidence for a pH sensor of erythrocyte K-Cl cotransport through inhibition by internal protons and diethylpyrocarbonate.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Volume-sensitive K(+)/Cl(-) cotransport in rabbit erythrocytes. Analysis of the rate-limiting activation and inactivation events

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

[Cl-]i-dependent phosphorylation of the Na-K-Cl cotransport protein of dog tracheal epithelial cells.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Human hypertension caused by mutations in WNK kinases

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK4 kinase is a negative regulator of K+-Cl- cotransporters.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1 and WNK4 modulate CFTR activity.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Molecular evidence for a role for K(+)-Cl(-) cotransporters in the kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Aldosterone paradox: differential regulation of ion transport in distal nephron.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Aldosterone does not require angiotensin II to activate NCC through a WNK4-SPAK-dependent pathway

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Sites of regulated phosphorylation that control K-Cl cotransporter activity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Influence of WNK3 on intracellular chloride concentration and volume regulation in HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

A genome-wide association study of hypertension and blood pressure in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Role of the WNK-activated SPAK kinase in regulating blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Rare independent mutations in renal salt handling genes contribute to blood pressure variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

21 January 2018

Diuretic complications

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1 kinase isoform switch regulates renal potassium excretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Structural insights into the recognition of substrates and activators by the OSR1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Structure of the MST4 in complex with MO25 provides insights into its activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Structural insights into the activation of MST3 by MO25

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Structural insights into regulatory mechanisms of MO25-mediated kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

GABA regulates synaptic integration of newly generated neurons in the adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

How GABA generates depolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Expression of the Na-K-2Cl-cotransporter NKCC1 during mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Chloride extrusion enhancers as novel therapeutics for neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Diuretics and epilepsy: will the past and present meet?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

WNK1/HSN2 mutation in human peripheral neuropathy deregulates KCC2 expression and posterior lateral line development in zebrafish (Danio rerio)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

Regulation of K-Cl cotransport: from function to genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005365

10.1126/SCISIGNAL.2005365

21 January 2018

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release_u6ozvihgyzb6jcr5tym2wvftge

31 August 2017

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