Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes (Q38245901)

31 August 2017

title

Dorothy Hodgkin Lecture 2014. Understanding genes identified by genome-wide association studies for type 2 diabetes (English)

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genome-wide association study

31 August 2017

main subject

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

G A Rutter

series ordinal

1

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31 August 2017

publication date

1 December 2014

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31 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

31

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

1480-1487

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

UKPDS 26: Sulphonylurea failure in non-insulin-dependent diabetic patients over six years. UK Prospective Diabetes Study (UKPDS) Group.

31 May 2020

cites work

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

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Pancreatic beta-cell mass in European subjects with type 2 diabetes

21 January 2018

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Functional and molecular defects of pancreatic islets in human type 2 diabetes

21 January 2018

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The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis

21 January 2018

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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

21 January 2018

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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 January 2018

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Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

21 January 2018

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Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention

21 January 2018

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A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults

21 January 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

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TCF7L2: the biggest story in diabetes genetics since HLA?

21 January 2018

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

21 January 2018

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

21 January 2018

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TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

21 January 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

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A map of open chromatin in human pancreatic islets

21 January 2018

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TCF7L2 splice variants have distinct effects on beta-cell turnover and function

21 January 2018

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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

21 January 2018

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Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

21 January 2018

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Tissue-specific alternative splicing of TCF7L2.

21 January 2018

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RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

21 January 2018

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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

21 January 2018

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Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

21 January 2018

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Lipotoxicity disrupts incretin-regulated human β cell connectivity

21 January 2018

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

21 January 2018

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Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

21 January 2018

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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

21 January 2018

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

21 January 2018

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Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

21 January 2018

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A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

21 January 2018

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Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion

21 January 2018

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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

21 January 2018

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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

21 January 2018

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The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background

21 January 2018

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Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

21 January 2018

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The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

21 January 2018

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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

21 January 2018

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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

21 January 2018

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

21 January 2018

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Expression of adenylyl cyclase subtypes in pancreatic beta-cells

21 January 2018

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Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes

21 January 2018

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Incretin-modulated beta cell energetics in intact islets of Langerhans

21 January 2018

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

21 January 2018

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Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice

21 January 2018

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/DME.12579

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25186316%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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