TCF7L2 splice variants have distinct effects on beta-cell turnover and function (Q39584862)

13 September 2017

TCF7L2 splice variants have distinct effects on beta-cell turnover and function (English)

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13 September 2017

Bernadette Neve

4

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François Pattou

Francois Pattou

7

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Philippe Froguel

Philippe Froguel

8

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Olivier Le Bacquer

Olivier Le Bacquer

1

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Kathrin Maedler

Kathrin Maedler

9

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author name string

Luan Shu

2

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13 September 2017

Marion Marchand

3

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13 September 2017

Federico Paroni

5

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13 September 2017

Julie Kerr Conte

6

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13 September 2017

language of work or name

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28 February 2011

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13 September 2017

Human Molecular Genetics

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13 September 2017

20

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13 September 2017

1906-1915

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13 September 2017

10

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Wnt signaling regulates pancreatic beta cell proliferation

13 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

The transcription factor 7-like 2 gene and increased risk of type 2 diabetes: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Tissue-specific alternative splicing of TCF7L2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Survivin and molecular pathogenesis of colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Inhibition of GSK3 promotes replication and survival of pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

The new type 2 diabetes gene TCF7L2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Human islet transplantation: lessons from 13 autologous and 13 allogeneic transplantations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Monolayer Culture of Adult Rat Pancreatic Islets on Extracellular Matrix: Modulation of B-Cell Function by Chronic Exposure to High Glucose*

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

Beta-cell gene expression and functional characterisation of the human insulinoma cell line CM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDR072

21 January 2018

Identifiers

DOI

10.1093/HMG/DDR072

1 reference

13 September 2017

1 reference