Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death (Q38252321)

1 September 2017

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title

Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death (English)

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1 September 2017

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Ana M Villamil Giraldo

1

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1 September 2017

Hanna Appelqvist

2

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1 September 2017

Thomas Ederth

3

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1 September 2017

Karin Öllinger

4

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1 September 2017

1 October 2014

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Biochemical Society Transactions

1 September 2017

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1 September 2017

42

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1 September 2017

5

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1 September 2017

1460-1464

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The lysosome: from waste bag to potential therapeutic target

1 September 2017

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https://api.crossref.org/works/10.1042%2FBST20140145

Lysosomal membrane proteins: life between acid and neutral conditions

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

The proteome of lysosomes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Induction of cell death by the lysosomotropic detergent MSDH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Sphingosine-induced apoptosis is dependent on lysosomal proteases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Cytosolic acidification and lysosomal alkalinization during TNF-alpha induced apoptosis in U937 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Regulation of apoptosis-associated lysosomal membrane permeabilization

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Commentary. Lysosomotropic agents

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Effects of weakly basic amines on proteolytic processing and terminal glycosylation of secretory proteins in cultured rat hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

A high content screening assay for identifying lysosomotropic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Lysosome dysfunction triggers Atg7-dependent neural apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Cell killing by lysosomotropic detergents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

The role of lysosomal enzymes in killing of mammalian cells by the lysosomotropic detergent N-dodecylimidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Sphingosine forms channels in membranes that differ greatly from those formed by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Ceramide-orchestrated signalling in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

pH dependence of sphingosine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Sphingosine increases the permeability of model and cell membranes

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20140145

Biophysical Implications of Sphingosine Accumulation in Membrane Properties at Neutral and Acidic pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20140145

21 January 2018

Identifiers

DOI

10.1042/BST20140145

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1 September 2017

1 reference