The proteome of lysosomes (Q24303943)

Solute carrier family 35 member F6

GOA release 2020-03-11

1 reference

Solute carrier family 26 member 11

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Paul Saftig

4

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author name string

Bernd A Schröder

1

0 references

Christian Wrocklage

2

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Andrej Hasilik

The discovery of lysosomes

3

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language of work or name

English

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publication date

November 2010

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published in

Proteomics

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volume

10

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issue

22

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page(s)

4053-76

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cites work

1 reference

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Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

21 January 2018

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Chaperone-Mediated Autophagy

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The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

21 January 2018

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LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase

21 January 2018

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of the gene encoding the enzyme deficient in mucopolysaccharidosis IIIC (Sanfilippo disease type C)

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Mutations in TMEM76* cause mucopolysaccharidosis IIIC (Sanfilippo C syndrome)

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosomes: fusion and function

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosomal storage disorders

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Neuronal ceroid lipofuscinoses

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

Molecular and cellular basis of lysosomal transmembrane protein dysfunction

21 January 2018

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https://api.crossref.org/works/10.1002%2FPMIC.201000196

The novel neuronal ceroid lipofuscinosis gene MFSD8 encodes a putative lysosomal transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Autophagy in the Pathogenesis of Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Autophagy, amyloidogenesis and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosomal involvement in cell death and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Autophagy in atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Isolation of the major subcellular organelles from mouse liver using Nycodenz gradients without the use of an ultracentrifuge

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Two species of lysosomal organelles in cultured human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A method to assess the lysosomal residence of proteins in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton WR-1339. Improved isolation procedures, automated analysis, biochemical and morphological properties of fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

NCU-G1 is a highly glycosylated integral membrane protein of the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Characterisation of lipofuscin-like lysosomal inclusion bodies from human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Integral and associated lysosomal membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

You say lipofuscin, we say ceroid: defining autofluorescent storage material

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

GEE MV: Rate and magnitude of age pigment accumulation in the human myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Rate of accumulation of cardiac lipofuscin in the aging canine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The lysosomal-mitochondrial axis theory of postmitotic aging and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Potential role of retinal pigment epithelial lipofuscin accumulation in age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lipofuscin (aging) pigment granules of the newborn human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteome analysis of lipofuscin in human retinal pigment epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of novel lysosomal matrix proteins by proteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Towards a human repertoire of monocytic lysosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomic analysis of human lysosomes: application to monocytic and breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The human brain mannose 6-phosphate glycoproteome: a complex mixture composed of multiple isoforms of many soluble lysosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of sites of mannose 6-phosphorylation on lysosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The human urine mannose 6-phosphate glycoproteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The mannose 6-phosphate glycoprotein proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Biochemical characterization and lysosomal localization of the mannose-6-phosphate protein p76 (hypothetical protein LOC196463)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomics of the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosomal transport disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Molecular physiology and pathophysiology of lysosomal membrane transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosomal membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

LAMP proteins are required for fusion of lysosomes with phagosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A new gene, encoding an anion transporter, is mutated in sialic acid storage diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Isolation of a novel gene underlying batten disease, CLN3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A model for random sampling and estimation of relative protein abundance in shotgun proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Comparison of label-free methods for quantifying human proteins by shotgun proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Quantitative mass spectrometry in proteomics: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomic characterization of the human centrosome by protein correlation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

A mammalian organelle map by protein correlation profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Intracellular localization of p40, a protein identified in a preparation of lysosomal membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Vesicular localization of the rat ATP-binding cassette half-transporter rAbcb6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The phagosome proteome: insight into phagosome functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Modulation of the phagosome proteome by interferon-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Membrane proteomics of phagosomes suggests a connection to autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

ER-mediated phagocytosis: a new membrane for new functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Quantitative and dynamic assessment of the contribution of the ER to phagosome formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

"Subcellular proteomics" of neuromelanin granules isolated from the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Mass spectrometry-based protein profiling to determine the cause of lysosomal storage diseases of unknown etiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of HE1 as the second gene of Niemann-Pick C disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Localisation of a gene for mucopolysaccharidosis IIIC to the pericentromeric region of chromosome 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

V-ATPase functions in normal and disease processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The Arf-family protein, Arl8b, is involved in the spatial distribution of lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Functional characterization of wild-type and mutant human sialin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of a vesicular aspartate transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

TRPML and lysosomal function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Mucolipins: Intracellular TRPML1-3 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

GLUT8, the enigmatic intracellular hexose transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification and characterization of a lysosomal transporter for small neutral amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

ABC transporter A3 facilitates lysosomal sequestration of imatinib and modulates susceptibility of chronic myeloid leukemia cell lines to this drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Identification of a lysosomal peptide transport system induced during dendritic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Biosynthesis and intracellular targeting of the CLN3 protein defective in Batten disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

The structure and function of the Niemann-Pick C1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

TMEM74, a lysosome and autophagosome protein, regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Two-dimensional mapping and microsequencing of lysosomal proteins from human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

Isolation of Golgi membranes from tissues and cells by differential and density gradient centrifugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Lysosomal proteolysis of prosaposin, the precursor of saposins (sphingolipid activator proteins): its mechanism and inhibition by ganglioside

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

The preparation of subcellular organelles from mouse liver in self-generated gradients of iodixanol

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Isolation of highly purified rat liver lysosomal membranes using two Percoll gradients

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Rupture of rat liver lysosomes mediated by L-amino acid esters

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Method for the isolation of iron-loaded lysosomes from rat liver

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

A protocol for combined delipidation and subfractionation of membrane proteins using organic solvents

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Identification of a mammalian mitochondrial porphyrin transporter

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Cloning of a lymphatic peptide/histidine transporter

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Identification and validation of mannose 6-phosphate glycoproteins in human plasma reveal a wide range of lysosomal and non-lysosomal proteins

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Proteomics analysis of serum from mutant mice reveals lysosomal proteins selectively transported by each of the two mannose 6-phosphate receptors

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

A gene network regulating lysosomal biogenesis and function

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Proteomic Analysis of Membrane-Associated Proteins from Rat Liver Autophagosomes

1 reference

https://api.crossref.org/works/10.1002%2FPMIC.201000196

7 January 2021

Identifiers

DOI

10.1002/PMIC.201000196

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

20957757

1 reference

Consolidated OpenCitations Corpus – April 2017