SLC30A8 mutations in type 2 diabetes (Q38257329)

1 September 2017

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title

SLC30A8 mutations in type 2 diabetes (English)

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1 September 2017

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Fabrice Chimienti

2

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Guy A. Rutter

series ordinal

1

object named as

Guy A Rutter

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1 September 2017

7 October 2014

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1 September 2017

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1 September 2017

58

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1 September 2017

31-36

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1 September 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00125-014-3405-7

1 September 2017

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cites work

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21 January 2018

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Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

21 January 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

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Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

21 January 2018

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21 January 2018

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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

21 January 2018

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The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study.

21 January 2018

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Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

21 January 2018

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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

21 January 2018

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

21 January 2018

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Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

21 January 2018

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The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

21 January 2018

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The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

21 January 2018

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Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W.

21 January 2018

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21 January 2018

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A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

21 January 2018

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21 January 2018

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ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells

21 January 2018

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Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.

21 January 2018

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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

21 January 2018

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The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influenced by gender and genetic background

21 January 2018

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Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

21 January 2018

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Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

21 January 2018

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21 January 2018

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21 January 2018

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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

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Zinc as a paracrine effector in pancreatic islet cell death

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21 January 2018

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21 January 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

21 January 2018

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TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

21 January 2018

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21 January 2018

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Mammalian basal metabolic rate is proportional to body mass2/3.

21 January 2018

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A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients

21 January 2018

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The reduced secretion of, and sensitivity to insulin in zinc-deficient rats

21 January 2018

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12 December 2020

SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes

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12 December 2020

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12 December 2020

Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice

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12 December 2020

Insulin-like effect of zinc on adipocytes

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12 December 2020

10.1007/S00125-014-3405-7

Identifiers

DOI

1 reference

PubMed ID

25287711

Dimensions Publication ID

1 September 2017

0 references

1 reference

PubMed ID

25287711