Iron regulatory proteins and their role in controlling iron metabolism (Q38259243)

1 September 2017

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title

Iron regulatory proteins and their role in controlling iron metabolism (English)

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1 September 2017

Lukas C Kühn

1

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1 September 2017

1 February 2015

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1 September 2017

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1 September 2017

7

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1 September 2017

232-243

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1 September 2017

2

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Iron speciation in the cytosol: an overview

1 September 2017

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A cytosolic iron chaperone that delivers iron to ferritin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Novel mechanism for translational control in regulation of ferritin synthesis by iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A cytosolic protein binds to structural elements within the iron regulatory region of the transferrin receptor mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Translational regulation in vivo of the Drosophila melanogaster mRNA encoding succinate dehydrogenase iron protein via iron responsive elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-dependent regulation of the divalent metal ion transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A novel iron responsive element in the 3'UTR of human MRCKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences

21 January 2018

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https://api.crossref.org/works/10.1039%2FC4MT00164H

Differences in the RNA binding sites of iron regulatory proteins and potential target diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A model of the iron responsive element RNA hairpin loop structure determined from NMR and thermodynamic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Nucleotide-specific recognition of iron-responsive elements by iron regulatory protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Crystal structure of human iron regulatory protein 1 as cytosolic aconitase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Serum transferrin receptor as an index of iron absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Assessment of iron status

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Maturation of cytosolic and nuclear iron-sulfur proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Dre2, a conserved eukaryotic Fe/S cluster protein, functions in cytosolic Fe/S protein biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

A novel eukaryotic factor for cytosolic Fe-S cluster assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Nitrosative and oxidative modulation of iron regulatory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Aconitase as Ironminus signSulfur Protein, Enzyme, and Iron-Regulatory Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Effect of reactive oxygen species on iron regulatory protein activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Thioredoxin activation of iron regulatory proteins. Redox regulation of RNA binding after exposure to nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Hypoxia post-translationally activates iron-regulatory protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Oxygen and iron regulation of iron regulatory protein 2.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

The role of endogenous heme synthesis and degradation domain cysteines in cellular iron-dependent degradation of IRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-dependent degradation of IRP2 requires its C-terminal region and IRP structural integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Control of iron homeostasis by an iron-regulated ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

21 January 2018

Dioxygen and Hemerythrin

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Nitric oxide and peroxynitrite activate the iron regulatory protein-1 of J774A.1 macrophages by direct disassembly of the Fe-S cluster of cytoplasmic aconitase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Redox control of iron regulatory protein 2 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron regulatory proteins control a mucosal block to intestinal iron absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Identification of an intestinal heme transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Heme transport and erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Evolution of the iron-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Binding of a cytosolic protein to the iron-responsive element of human ferritin messenger RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Recombinant iron-regulatory factor functions as an iron-responsive-element-binding protein, a translational repressor and an aconitase. A functional assay for translational repression and direct demonstration of the iron switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00164H

21 January 2018

Identifiers

DOI

10.1039/C4MT00164H

1 reference

1 September 2017

1 reference

PubMed ID

25306858