Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance (Q38275050)

1 September 2017

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title

Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance (English)

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1 September 2017

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Caitriona M O'Driscoll

object named as

Caitriona M O'Driscoll

5

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John F. Cryan

object named as

John F Cryan

4

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author name string

David J Mc Carthy

1

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1 September 2017

Meenakshi Malhotra

2

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1 September 2017

Aoife M O'Mahony

3

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1 September 2017

language of work or name

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2 December 2014

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1 September 2017

published in

Pharmaceutical Research

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1 September 2017

volume

32

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1 September 2017

issue

4

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1 September 2017

page(s)

1161-1185

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21 January 2018

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Transport of nanoparticles through the blood-brain barrier for imaging and therapeutic applications

21 January 2018

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Active targeting of brain tumors using nanocarriers

21 January 2018

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Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.

21 January 2018

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Brain drug targeting and gene technologies

21 January 2018

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21 January 2018

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Nano-sized cationic polymeric magnetic liposomes significantly improves drug delivery to the brain in rats

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles

21 January 2018

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Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery

21 January 2018

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21 January 2018

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Evaluation of neuropeptide loaded trimethyl chitosan nanoparticles for nose to brain delivery

21 January 2018

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Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model

21 January 2018

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In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery

21 January 2018

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Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications

21 January 2018

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Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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MMP-9 gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement

21 January 2018

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Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer

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21 January 2018

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A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

21 January 2018

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21 January 2018

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Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier

21 January 2018

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Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

21 January 2018

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Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance

21 January 2018

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A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles

21 January 2018

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Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery

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Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis

21 January 2018

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Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells

21 January 2018

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Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats

21 January 2018

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Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

21 January 2018

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Transport of nerve growth factor encapsulated into liposomes across the blood-brain barrier: in vitro and in vivo studies

21 January 2018

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Quaternary ammonium beta-cyclodextrin nanoparticles for enhancing doxorubicin permeability across the in vitro blood-brain barrier

21 January 2018

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Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor

21 January 2018

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21 January 2018

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Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy

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Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting.

21 January 2018

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The use of pigs in neuroscience: modeling brain disorders

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21 January 2018

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Nanoparticulate transport of oximes over an in vitro blood-brain barrier model

21 January 2018

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Receptor-mediated delivery of magnetic nanoparticles across the blood-brain barrier

21 January 2018

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Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles

21 January 2018

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Solid lipid nanoparticles carrying chemotherapeutic drug across the blood-brain barrier through insulin receptor-mediated pathway

21 January 2018

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Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma

21 January 2018

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Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment

21 January 2018

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Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies

21 January 2018

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Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells

21 January 2018

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Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model

21 January 2018

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Effect of surface charge of immortalized mouse cerebral endothelial cell monolayer on transport of charged solutes

21 January 2018

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Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells

21 January 2018

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Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line

21 January 2018

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Internal benchmarking of a human blood-brain barrier cell model for screening of nanoparticle uptake and transcytosis

21 January 2018

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Binding, transcytosis and biodistribution of anti-PECAM-1 iron oxide nanoparticles for brain-targeted delivery

21 January 2018

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A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.

21 January 2018

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Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models

21 January 2018

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Monitoring the transport of polymeric micelles across MDCK cell monolayer and exploring related mechanisms

21 January 2018

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Comparative evaluation of the degree of pegylation of poly(lactic-co-glycolic acid) nanoparticles in enhancing central nervous system delivery of loperamide.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

The role of shear stress in Blood-Brain Barrier endothelial physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Translational CNS medicines research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Challenges in development of nanoparticle-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Endocytosis of nanomedicines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Nanoparticle accumulation and transcytosis in brain endothelial cell layers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

68Ga-labeled gold glyconanoparticles for exploring blood-brain barrier permeability: preparation, biodistribution studies, and improved brain uptake via neuropeptide conjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Efficacy of Cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood-brain barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Effects of surface modification of PLGA-PEG-PLGA nanoparticles on loperamide delivery efficiency across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Transferrin adsorption onto PLGA nanoparticles governs their interaction with biological systems from blood circulation to brain cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Apolipoprotein A-I coating of protamine-oligonucleotide nanoparticles increases particle uptake and transcytosis in an in vitro model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Analysis of biotinylated generation 4 poly(amidoamine) (PAMAM) dendrimer distribution in the rat brain and toxicity in a cellular model of the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

In vitro and in vivo investigation of glucose-mediated brain-targeting liposomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Anti-Aβ-MAb and dually decorated nanoliposomes: effect of Aβ1-42 peptides on interaction with hCMEC/D3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

In vitro evidence of dysregulation of blood-brain barrier function after acute and repeated/long-term exposure to TiO(2) nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

In vitro and in vivo studies on the transport of PEGylated silica nanoparticles across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Cell-based in vitro blood-brain barrier model can rapidly evaluate nanoparticles' brain permeability in association with particle size and surface modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Targeted brain derived neurotropic factors (BDNF) delivery across the blood-brain barrier for neuro-protection using magnetic nano carriers: an in-vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Methylmethacrylate-sulfopropylmethacrylate nanoparticles with surface RMP-7 for targeting delivery of antiretroviral drugs across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

A detailed method for preparation of a functional and flexible blood-brain barrier model using porcine brain endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

A Comprehensive Model for the Cellular Uptake of Cationic Cell-penetrating Peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Drug transport across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

Facilitated brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultrasound

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1545-6

The potential for nanoparticle-based drug delivery to the brain: overcoming the blood-brain barrier

21 January 2018

1 reference

12 December 2020

Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells

1 reference

12 December 2020

Polymeric emulsion and crosslink-mediated synthesis of super-stable nanoparticles as sustained-release anti-tuberculosis drug carriers

1 reference

12 December 2020

Body distribution of polysorbate-80 and doxorubicin-loaded [14C]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats

1 reference

12 December 2020

Pathways for small molecule delivery to the central nervous system across the blood-brain barrier

1 reference

12 December 2020

Gold nanoparticles delivery in mammalian live cells: a critical review

1 reference

12 December 2020

On the toxicity of therapeutically used nanoparticles: an overview

1 reference

12 December 2020

Animal models got you puzzled?: think pig

1 reference

12 December 2020

Nanoparticulate systems in drug delivery and targeting

1 reference

12 December 2020

Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier

1 reference

12 December 2020

Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro

1 reference

12 December 2020

Intranasal, siRNA Delivery to the Brain by TAT/MGF Tagged PEGylated Chitosan Nanoparticles.

1 reference

12 December 2020

Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

1 reference

12 December 2020

2013 Alzheimer's disease facts and figures

1 reference

12 December 2020

Preparation and properties of nanoscale containers for biomedical application in drug delivery: preliminary studies with kynurenic acid

1 reference

12 December 2020

Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles

1 reference

12 December 2020

Lipid-DNA and lipid-polyelectrolyte mesophases: structure and exchange kinetics.

1 reference

12 December 2020

Transferrin-conjugated liposomal system for improved delivery of 5-fluorouracil to brain

1 reference

12 December 2020

Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies

1 reference

12 December 2020

Theranostic quantum dots for crossing blood-brain barrier in vitro and providing therapy of HIV-associated encephalopathy

1 reference

12 December 2020

Generation of an immortalized murine brain microvascular endothelial cell line as an in vitro blood brain barrier model

1 reference

12 December 2020

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

1 reference

12 December 2020

Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma

1 reference

12 December 2020

Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier

1 reference

12 December 2020

Liposomes functionalized to overcome the blood-brain barrier and to target amyloid-β peptide: the chemical design affects the permeability across an in vitro model.

1 reference

12 December 2020

10.1007/S11095-014-1545-6

Identifiers

DOI

1 reference

1 September 2017

1 reference