ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint (Q38294681)

1 September 2017

ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint (English)

1 reference

1 September 2017

Bimal N Desai

4

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Paul Nghiem

object named as

Paul Nghiem

1

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author name string

Peter K Park

2

1 reference

1 September 2017

Yong-son Kim Ys

3

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1 September 2017

Stuart L Schreiber

5

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1 September 2017

language of work or name

English

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publication date

15 November 2001

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Journal of Biological Chemistry

1 September 2017

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1 September 2017

277

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1 September 2017

6

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1 September 2017

4428-4434

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https://api.crossref.org/works/10.1074%2FJBC.M106113200

1 September 2017

1 reference

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Substrate specificities and identification of putative substrates of ATM kinase family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

How p53 binds DNA as a tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Regulation of the G2/M transition by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

GADD45 induction of a G2/M cell cycle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

p53 inhibits entry into mitosis when DNA synthesis is blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Flow cytometry of mitotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106113200

21 January 2018

Identifiers

DOI

10.1074/JBC.M106113200

1 reference

1 September 2017

1 reference