tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes (Q38319824)

2 September 2017

tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes (English)

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2 September 2017

Richard Bowater

3

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author name string

Korden Walter

1

1 reference

2 September 2017

Gabriele Warnecke

2

1 reference

2 September 2017

Wolfgang Deppert

4

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2 September 2017

Ella Kim

5

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2 September 2017

language of work or name

English

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publication date

17 October 2005

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

280

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2 September 2017

52

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2 September 2017

42497-42507

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Sensing and responding to DNA damage.

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The S phase checkpoint: when the crowd meets at the fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

DNA damage tumor suppressor genes and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Multiple roles of the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

p53-mediated apoptosis and genomic instability diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

p53 binds telomeric single strand overhangs and t-loop junctions in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Modulation of p53 binding to Holliday junctions and 3-cytosine bulges by phosphorylation events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The N terminus of p53 regulates its dissociation from DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The complex interactions of p53 with target DNA: we learn as we go.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

p53 domains: identification and characterization of two autonomous DNA-binding regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Mutant p53 proteins bind DNA in a DNA structure-selective mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Activation of p53 protein by telomeric (TTAGGG)n repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Non-B DNA conformations, genomic rearrangements, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Advances in mechanisms of genetic instability related to hereditary neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Structural features of trinucleotide repeats associated with DNA expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding. An NMR and UV spectroscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Trinucleotide repeats associated with human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Structural roles of CTG repeats in slippage expansion during DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

DNA recognition by DNase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Analysis of p53 "latency" and "activation" by fluorescence correlation spectroscopy. Evidence for different modes of high affinity DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

PatSearch: A program for the detection of patterns and structural motifs in nucleotide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Isolation of p53-target genes and their functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Association of p53 and MSH2 with recombinative repair complexes during S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Genetic Stabilization by p53 Involves Growth Regulatory and Repair Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Denaturation of dsDNA by p53: fluorescence correlation spectroscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Purification and characterization of the single-stranded DNA binding protein from Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M507038200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507038200

1 reference

2 September 2017

1 reference