The complex interactions of p53 with target DNA: we learn as we go. (Q35191541)

7 August 2017

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title

The complex interactions of p53 with target DNA: we learn as we go. (English)

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7 August 2017

Ella Kim

1

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PubMed ID

12897847

7 August 2017

Wolfgang Deppert

series ordinal

2

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7 August 2017

1 June 2003

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Biochemistry and Cell Biology

7 August 2017

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7 August 2017

81

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7 August 2017

3

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7 August 2017

141-150

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Recruitment of p300/CBP in p53-dependent signal pathways

7 August 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.

21 January 2018

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Rescuing the function of mutant p53.

21 January 2018

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The role of tetramerization in p53 function

21 January 2018

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A polymorphic microsatellite that mediates induction of PIG3 by p53.

21 January 2018

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Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53

21 January 2018

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Binding of MAR-DNA elements by mutant p53: possible implications for its oncogenic functions

21 January 2018

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Definition of a consensus binding site for p53

21 January 2018

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Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

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The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

21 January 2018

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Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain

21 January 2018

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Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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Synergistic activation of transcription by CBP and p53

21 January 2018

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The p53MH algorithm and its application in detecting p53-responsive genes

21 January 2018

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Allosteric activation of latent p53 tetramers

21 January 2018

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Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases

21 January 2018

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Regulation of the specific DNA binding function of p53

21 January 2018

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Molecular cloning and functional analysis of the murine bax gene promoter

21 January 2018

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Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.

21 January 2018

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High mobility group protein-1 (HMG-1) is a unique activator of p53

21 January 2018

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.

21 January 2018

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ATP-dependent remodeling and acetylation as regulators of chromatin fluidity

21 January 2018

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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

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Cancer. p53, guardian of the genome

21 January 2018

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T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

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p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

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Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status

21 January 2018

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Selective binding of different p53 response elements by p53 containing complexes

21 January 2018

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Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain

21 January 2018

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Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein

21 January 2018

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Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

21 January 2018

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Activation of p53 protein by telomeric (TTAGGG)n repeats

21 January 2018

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

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Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

21 January 2018

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

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Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

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p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression

21 January 2018

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Tumor suppressor protein p53 binds preferentially to supercoiled DNA.

21 January 2018

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Binding of p53 and its core domain to supercoiled DNA.

21 January 2018

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A model for p53-induced apoptosis

21 January 2018

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Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

21 January 2018

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Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

21 January 2018

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Assessing TP53 status in human tumours to evaluate clinical outcome

21 January 2018

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p53 binds telomeric single strand overhangs and t-loop junctions in vitro

21 January 2018

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Kinetics of p53 binding to promoter sites in vivo

21 January 2018

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One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element

21 January 2018

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p53 tagged sites from human genomic DNA.

21 January 2018

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Unusual DNA structures, chromatin and transcription

21 January 2018

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21 January 2018

Surfing the p53 network

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Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

21 January 2018

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Interaction of p53 with its consensus DNA-binding site

21 January 2018

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hADA3 is required for p53 activity

21 January 2018

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The dynamic distribution and quantification of DNA cruciforms in eukaryotic nuclei

21 January 2018

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High affinity MAR-DNA binding is a common property of murine and human mutant p53.

21 January 2018

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p53 binds to a constitutively nucleosome free region of the mdm2 gene

21 January 2018

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

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Virus-mediated killing of cells that lack p53 activity

21 January 2018

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The C-terminus of p53: the more you learn the less you know

21 January 2018

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Atomic force microscopy reveals kinks in the p53 response element DNA

21 January 2018

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

21 January 2018

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Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53

21 January 2018

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Analysis of the binding of p53 to DNAs containing mismatched and bulged bases

21 January 2018

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Scanning force microscopy of the complexes of p53 core domain with supercoiled DNA

21 January 2018

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DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53

21 January 2018

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Human p53 binds Holliday junctions strongly and facilitates their cleavage

21 January 2018

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Flexibility: the key to p53 function?

21 January 2018

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Inverted repeats, stem-loops, and cruciforms: Significance for initiation of DNA replication

21 January 2018

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Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites

21 January 2018

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The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

21 January 2018

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A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O03-046

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7 August 2017

1 reference

PubMed ID

12897847