Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences. (Q38330456)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

review article

1 reference

title

Probing SGLT2 as a therapeutic target for diabetes: basic physiology and consequences (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

1

1 reference

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28 February 2020

Volker Vallon

series ordinal

3

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28 February 2020

author name string

Ernest M Wright

series ordinal

2

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28 February 2020

language of work or name

English

0 references

publication date

23 January 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json

Diabetes and Vascular Disease Research

28 February 2020

published in

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28 February 2020

volume

12

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28 February 2020

page(s)

78-89

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28 February 2020

issue

2

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The mechanisms and therapeutic potential of SGLT2 inhibitors in diabetes mellitus.

28 February 2020

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Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.

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Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice.

10 July 2018

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Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes

10 July 2018

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Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats

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Canagliflozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study

10 July 2018

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Effects of SGLT2 inhibition in human kidney proximal tubular cells--renoprotection in diabetic nephropathy?

10 July 2018

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10 July 2018

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Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

10 July 2018

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LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial.

10 July 2018

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Regulation of the human Na+-dependent glucose cotransporter hSGLT2.

10 July 2018

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Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney

10 July 2018

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Bridging the gap between structure and kinetics of human SGLT1.

10 July 2018

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Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion

10 July 2018

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Structural selectivity of human SGLT inhibitors

10 July 2018

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Acute and chronic effects of SGLT2 blockade on glomerular and tubular function in the early diabetic rat

10 July 2018

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A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials

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10 July 2018

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The proximal tubule in the pathophysiology of the diabetic kidney

10 July 2018

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10 July 2018

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10 July 2018

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The mechanism of sodium and substrate release from the binding pocket of vSGLT

10 July 2018

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10 July 2018

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SGLT2 mediates glucose reabsorption in the early proximal tubule.

10 July 2018

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Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

10 July 2018

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SGLT2 inhibition--a novel strategy for diabetes treatment

10 July 2018

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Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.

10 July 2018

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Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats

10 July 2018

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Glucose control and vascular complications in veterans with type 2 diabetes

10 July 2018

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SLC2A9 is a high-capacity urate transporter in humans

10 July 2018

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10-year follow-up of intensive glucose control in type 2 diabetes

10 July 2018

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The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

10 July 2018

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Effects of intensive glucose lowering in type 2 diabetes

10 July 2018

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Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

10 July 2018

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10 July 2018

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THE ACTION OF PHLORIZIN ON THE EXCRETION OF GLUCOSE, XYLOSE, SUCROSE, CREATININE AND UREA BY MAN.

10 July 2018

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10 July 2018

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Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption

10 July 2018

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Conformational changes in the intestinal brush border sodium-glucose cotransporter labeled with fluorescein isothiocyanate

10 July 2018

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Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats

10 July 2018

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Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters

10 July 2018

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Expression cloning and cDNA sequencing of the Na+/glucose co-transporter

10 July 2018

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Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter

10 July 2018

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Distribution of the SGLT1 Na+/glucose cotransporter and mRNA along the crypt-villus axis of rabbit small intestine

10 July 2018

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Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter

10 July 2018

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Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry

10 July 2018

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Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial.

10 July 2018

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Sodium-glucose co-transporter 2 inhibitors and the potential for cardiovascular risk reduction in patients with type 2 diabetes mellitus.

31 August 2018

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Improved glycemic control in mice lacking Sglt1 and Sglt2.

31 August 2018

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Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin

31 August 2018

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Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial

31 August 2018

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Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects

31 August 2018

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Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes

31 August 2018

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Long-term outcome of renal glucosuria type 0: the original patient and his natural history

31 August 2018

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Role of KCNE1-dependent K+ fluxes in mouse proximal tubule

31 August 2018

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Differences in active and passive glucose transport along the proximal nephron

31 August 2018

1 reference

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Luseogliflozin: First Global Approval

31 August 2018

1 reference

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Risk of Cardiac Arrhythmias During Hypoglycemia in Patients With Type 2 Diabetes and Cardiovascular Risk

3 December 2018

1 reference

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Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent

3 December 2018

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12 December 2020

Isolation of (a subunit of) the Na+ /D-glucose contransporter(s) of rabbit intestinal brush border membranes using monoclonal antibodies

1 reference

12 December 2020

Dapagliflozin added to usual care in individuals with type 2 diabetes mellitus with preexisting cardiovascular disease: a 24-week, multicenter, randomized, double-blind, placebo-controlled study with a 28-week extension

1 reference

12 December 2020

Localization of Na(+)-dependent active type and erythrocyte/HepG2-type glucose transporters in rat kidney: immunofluorescence and immunogold study

1 reference

12 December 2020

Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption

1 reference

12 December 2020

Heterogeneity of sodium-dependent D-glucose transport sites along the proximal tubule: evidence from vesicle studies

1 reference

12 December 2020

Immunohistochemical localization of Na+-dependent glucose transporter in rat jejunum

1 reference

12 December 2020

Intestinal and renal Na+/glucose cotransporters share common structures

1 reference

12 December 2020

Identifiers

DOI

10.1177/1479164114561992

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25616707%20AND%20SRC:MED&resulttype=core&format=json