Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma. (Q38332451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21863061%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma (English)

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11 February 2020

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5

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11 February 2020

author name string

Ulrike Maegdefrau

1

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11 February 2020

Stephanie Arndt

2

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11 February 2020

Georgi Kivorski

3

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11 February 2020

Claus Hellerbrand

4

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11 February 2020

publication date

22 August 2011

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11 February 2020

published in

Laboratory Investigation

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11 February 2020

volume

91

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11 February 2020

issue

11

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11 February 2020

page(s)

1615-1623

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https://scigraph.springernature.com/pub.10.1038/labinvest.2011.123

11 February 2020

exact match

0 references

cites work

Iron absorption and metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Hepcidin inhibits apical iron uptake in intestinal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Collagen sandwich culture affects intracellular polyamine levels of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Functional implication of BMP4 expression on angiogenesis in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

De-regulation of common housekeeping genes in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Transferrin receptor 2 is crucial for iron sensing in human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Expression of hepcidin and other iron-regulatory genes in human hepatocellular carcinoma and its clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Modulation of iron-regulatory genes in human hepatocellular carcinoma and its physiological consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Cloning and characterization of a human type II receptor for bone morphogenetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Circulating interleukin-6 as a tumor marker for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Diferric transferrin regulates transferrin receptor 2 protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Bone morphogenetic protein 7 induces mesenchymal-to-epithelial transition in melanoma cells, leading to inhibition of metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

Iron-Induced Expression of Bone Morphogenic Protein 6 in Intestinal Cells Is the Main Regulator of Hepatic Hepcidin Expression In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

7 January 2021

Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

7 January 2021

HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

7 January 2021

Hepcidin and hemojuvelin gene expression in rat liver damage: in vivo and in vitro studies

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

7 January 2021

Abnormal iron uptake and liver cancer

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2011.123

7 January 2021

10.1038/LABINVEST.2011.123

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21863061%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 February 2020

0 references

1 reference