Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. (Q38334505)

2 September 2017

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. (English)

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2 September 2017

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2 September 2017

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Eric Santoni-Rugiu

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Christian Holmberg

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Christian Holmberg

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author name string

Karl Agger

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2 September 2017

Eric Santoni-Rugiu

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2 September 2017

Olle Karlström

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2 September 2017

language of work or name

English

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publication date

1 January 2005

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2 September 2017

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2 September 2017

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2 September 2017

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2 September 2017

780-789

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208248

2 September 2017

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cites work

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Emerging roles for E2F: Beyond the G1/S transition and DNA replication

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E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

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Genomic instability in mice lacking histone H2AX

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Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors

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Requirement for a functional Rb-1 gene in murine development

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation

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Drosophila myc regulates organ size by inducing cell competition

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

21 January 2018

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E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes

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Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

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A ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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The role of p53 and pRB in apoptosis and cancer

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E2F-1-induced p53-independent apoptosis in transgenic mice.

21 January 2018

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DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse

21 January 2018

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

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E2F4 is essential for normal erythrocyte maturation and neonatal viability

21 January 2018

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

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Effects of an Rb mutation in the mouse

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression

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Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

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dMyc transforms cells into super-competitors

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An E2F-like repressor of transcription.

21 January 2018

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E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

21 January 2018

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Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.

21 January 2018

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Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors.

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

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Loss of E2F4 activity leads to abnormal development of multiple cellular lineages

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

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The RB and p53 pathways in cancer

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E2F-6, a member of the E2F family that can behave as a transcriptional repressor

21 January 2018

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Sibling rivalry in the E2F family

21 January 2018

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

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The E2F1-3 transcription factors are essential for cellular proliferation.

21 January 2018

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INK4d-deficient mice are fertile despite testicular atrophy

21 January 2018

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Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

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Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

21 January 2018

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7 January 2021

Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

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7 January 2021

The methylation-free status of a housekeeping transgene is lost at high copy number

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7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

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7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

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7 January 2021

Origin, functions and chemistry of H-2 regulated odorants

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208248

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Dimensions Publication ID

2 September 2017

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