AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. (Q38340845)

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English	AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.	scientific article

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scholarly article

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Europe PubMed Central

2 September 2017

AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6957371&resulttype=core&format=json

13 May 2020

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Stephen E Alway

2

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13 May 2020

author name string

Joshua C Drake

1

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13 May 2020

John M Hollander

3

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13 May 2020

David L Williamson

4

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13 May 2020

publication date

15 September 2010

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2 September 2017

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

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13 May 2020

299

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13 May 2020

R1546-54

1 reference

Europe PubMed Central

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13 May 2020

6

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13 May 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6957371/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Dissecting the role of mTOR: lessons from mTOR inhibitors

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a rapamycin-sensitive pathway.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

The physiology of obese-hyperglycemic mice [ob/ob mice].

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Evaluation of mTOR function by a gain-of-function approach

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Long-term AICAR administration and exercise prevents diabetes in ZDF rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Suppression of cap-dependent translation in mitosis

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) Study.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Chronic high fat feeding attenuates load-induced hypertrophy in mice.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Management of side effects of sirolimus therapy

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Sarcopenic obesity: definition, cause and consequences

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Time course adaptations in rat skeletal muscle isomyosins during compensatory growth and regression

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women

1 reference

https://api.crossref.org/works/10.1152%2FAJPREGU.00337.2010

21 January 2018

Skeletal muscle growth in lean and obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle growth and satellite cell proliferative activity in obese (OB/OB) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Turnover rates of muscle proteins in cardiac, skeletal, and smooth muscle: turnover rate related to muscle function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postprandial stimulation of muscle protein synthesis is independent of changes in insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of insulin and IGF-I in activation of muscle protein synthesis after oral feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased protease activity in muscles of obese- (ob/ob) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indices of Skeletal Muscle Growth in Lean and Obese Zucker Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of peptide-chain initiation in rat skeletal muscle. Development of methods for preparation of native ribosomal subunits and analysis of the effect of insulin on formation of 40 S initiation complexes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic obesity and the muscle satellite cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The changing relationship of obesity and disability, 1988-2004

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic, nutritional and endocrine studies of the hereditary obesity-diabetes syndrome of mice and mechanism of its development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle protein turnover in the perfused hindquarters of lean and genetically obese-diabetic (db/db) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20844264

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPREGU.00337.2010

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6957371&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6957371&resulttype=core&format=json

13 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6957371&resulttype=core&format=json

13 May 2020

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