Targeted delivery of protein and gene medicines through the blood-brain barrier (Q38351122)

2 September 2017

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title

Targeted delivery of protein and gene medicines through the blood-brain barrier (English)

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2 September 2017

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1

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PubMed ID

25669455

2 September 2017

language of work or name

English

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publication date

15 December 2014

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Clinical Pharmacology & Therapeutics

2 September 2017

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2 September 2017

97

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2 September 2017

347-361

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2 September 2017

4

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A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group

2 September 2017

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Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF.

21 January 2018

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Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS.

21 January 2018

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Fiblast (trafermin) in acute stroke: results of the European-Australian phase II/III safety and efficacy trial

21 January 2018

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Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats.

21 January 2018

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Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats.

21 January 2018

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

21 January 2018

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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

21 January 2018

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Point source concentration of GDNF may explain failure of phase II clinical trial

21 January 2018

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Recombinant human erythropoietin in the treatment of acute ischemic stroke

21 January 2018

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Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse

21 January 2018

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Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force

21 January 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

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Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

21 January 2018

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Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography

21 January 2018

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Blood-brain barrier: interface between internal medicine and the brain

21 January 2018

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Cortical blood vessels of the human brain.

21 January 2018

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Glut1 glucose transporter activity in human brain injury.

21 January 2018

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Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

21 January 2018

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The blood-brain barrier: bottleneck in brain drug development

21 January 2018

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Selective expression of the large neutral amino acid transporter at the blood-brain barrier

21 January 2018

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The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.

21 January 2018

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Human blood-brain barrier insulin receptor

21 January 2018

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Human blood-brain barrier transferrin receptor

21 January 2018

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Blood-brain barrier transcytosis of insulin in developing rabbits

21 January 2018

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Receptor-mediated transcytosis of transferrin across the blood-brain barrier

21 January 2018

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Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

21 January 2018

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Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies

21 January 2018

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Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

21 January 2018

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IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys

21 January 2018

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Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

21 January 2018

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The roles of TNF in brain dysfunction and disease

21 January 2018

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Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

21 January 2018

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Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor

21 January 2018

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Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein

21 January 2018

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Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey

21 January 2018

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Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein

21 January 2018

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GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier

21 January 2018

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Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse

21 January 2018

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Re-engineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse

21 January 2018

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Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier

21 January 2018

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Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

21 January 2018

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Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins

21 January 2018

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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

21 January 2018

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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

21 January 2018

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Generation of dual-variable-domain immunoglobulin molecules for dual-specific targeting

21 January 2018

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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

21 January 2018

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Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

21 January 2018

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Gene therapy progress and prospects: gene therapy of lysosomal storage disorders

21 January 2018

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AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

21 January 2018

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Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein

21 January 2018

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Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

21 January 2018

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Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells

21 January 2018

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Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

21 January 2018

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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

21 January 2018

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Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein

21 January 2018

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Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

21 January 2018

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Global non-viral gene transfer to the primate brain following intravenous administration.

21 January 2018

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Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

21 January 2018

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Antisense gene therapy of brain cancer with an artificial virus gene delivery system

21 January 2018

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Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

21 January 2018

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Drug transport across the blood-brain barrier

21 January 2018

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Transport of [125I]transferrin through the rat blood-brain barrier

21 January 2018

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Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

21 January 2018

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A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

21 January 2018

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7 January 2021

Early blood-brain barrier disruption in human focal brain ischemia

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7 January 2021

The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor

1 reference

7 January 2021

Passage of erythropoietic agents across the blood-brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa

1 reference

7 January 2021

Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse

1 reference

7 January 2021

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

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7 January 2021

Identifiers

DOI

10.1002/CPT.18

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2 September 2017

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PubMed ID

25669455