The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer (Q38356629)

2 September 2017

The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer (English)

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2 September 2017

Mandy M Peak

1

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2 September 2017

Janeen L Arbuckle

series ordinal

2

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2 September 2017

Karla K Rodgers

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

18 March 2003

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

278

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2 September 2017

20

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2 September 2017

18235-18240

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

V(D)J recombination: RAG proteins, repair factors, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Identification of basic residues in RAG2 critical for DNA binding by the RAG1-RAG2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Conservation of sequence in recombination signal sequence spacers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

The genetic and biochemical basis of Omenn syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Partial V(D)J recombination activity leads to Omenn syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

V(D)J recombination: a functional definition of the joining signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

A zinc-binding domain involved in the dimerization of RAG1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302041200

21 January 2018

Identifiers

DOI

10.1074/JBC.M302041200

1 reference

2 September 2017

1 reference