Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores. (Q38494808)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26783362%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores (English)

1 reference

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5 March 2020

0 references

2

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5 March 2020

Joseph Unsay

5

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5 March 2020

Jonas Ries

8

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5 March 2020

Ana J García-Sáez

9

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5 March 2020

author name string

Raquel Salvador-Gallego

1

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5 March 2020

Katia Cosentino

3

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5 March 2020

Jale Schneider

4

1 reference

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5 March 2020

Ulrich Schraermeyer

6

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5 March 2020

Johann Engelhardt

7

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5 March 2020

language of work or name

English

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publication date

18 January 2016

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5 March 2020

1 reference

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5 March 2020

volume

35

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5 March 2020

issue

4

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5 March 2020

page(s)

389-401

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describes a project that uses

5 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4755116/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis

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Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species

6 September 2017

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More Than a Pore: The Interplay of Pore-Forming Proteins and Lipid Membranes.

6 September 2017

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Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.

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Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.

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Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers

6 September 2017

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Three-dimensional structure of Bax-mediated pores in membrane bilayers

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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

6 September 2017

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6 September 2017

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

6 September 2017

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6 September 2017

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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

6 September 2017

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Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

6 September 2017

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Bax forms an oligomer via separate, yet interdependent, surfaces

6 September 2017

1 reference

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Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy

6 September 2017

1 reference

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

6 September 2017

1 reference

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Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

6 September 2017

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

6 September 2017

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

6 September 2017

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Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

6 September 2017

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

6 September 2017

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

6 September 2017

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Structure of Bax: coregulation of dimer formation and intracellular localization

6 September 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

6 September 2017

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Movement of Bax from the cytosol to mitochondria during apoptosis

6 September 2017

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6 September 2017

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Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

14 September 2017

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Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

14 September 2017

1 reference

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Cascades of transient pores in giant vesicles: line tension and transport.

14 September 2017

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Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL.

14 September 2017

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Structural model of active Bax at the membrane.

27 September 2017

1 reference

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Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size

23 June 2018

1 reference

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Pores formed by Baxα5 relax to a smaller size and keep at equilibrium

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

23 June 2018

1 reference

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Cardiolipin effects on membrane structure and dynamics.

23 June 2018

1 reference

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Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Binding-activated localization microscopy of DNA structures.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Molecular details of Bax activation, oligomerization, and membrane insertion.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Assembly of streptolysin O pores assessed by quartz crystal microbalance and atomic force microscopy provides evidence for the formation of anchored but incomplete oligomers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4755116

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26783362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26783362

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201593384

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26783362%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26783362%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26783362%20AND%20SRC:MED&resulttype=core&format=json