P-glycoprotein and membrane roles in multidrug resistance. (Q38523606)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

review article

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title

P-glycoprotein and membrane roles in multidrug resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

main subject

multiple drug resistance

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

author name string

Ricardo J Ferreira

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

Maria-José U Ferreira

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

publication date

1 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

Future Medicinal Chemistry

16 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

volume

7

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16 February 2020

issue

7

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16 February 2020

page(s)

929-946

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26061109%20AND%20SRC:MED&resulttype=core&format=json

Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

16 February 2020

cites work

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ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

21 January 2018

1 reference

Mechanisms of cancer drug resistance

21 January 2018

1 reference

Simple Allosteric Model for Membrane Pumps

21 January 2018

1 reference

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

21 January 2018

1 reference

Cyclosporin A and its analogues as modifiers of adriamycin and vincristine resistance in a multi-drug resistant human lung cancer cell line

21 January 2018

1 reference

Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein

21 January 2018

1 reference

Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance

21 January 2018

1 reference

In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants

21 January 2018

1 reference

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

21 January 2018

1 reference

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 January 2018

1 reference

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane

21 January 2018

1 reference

Is the multidrug transporter a flippase?

21 January 2018

1 reference

P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

21 January 2018

1 reference

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

1 reference

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

21 January 2018

1 reference

Structure of lipid bilayers

21 January 2018

1 reference

The fluid mosaic model of the structure of cell membranes

21 January 2018

1 reference

Membranes are more mosaic than fluid

21 January 2018

1 reference

Flip-flop of doxorubicin across erythrocyte and lipid membranes

21 January 2018

1 reference

Probing the interface between membrane proteins and membrane lipids by X-ray crystallography

21 January 2018

1 reference

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

1 reference

The ATPase and ATP-binding functions of P-glycoprotein--modulation by interaction with defined phospholipids

21 January 2018

1 reference

The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter

21 January 2018

1 reference

P-glycoprotein effect on the properties of its natural lipid environment probed by Raman spectroscopy and Langmuir-Blodgett technique

21 January 2018

1 reference

Lipid bilayer properties control membrane partitioning, binding, and transport of p-glycoprotein substrates.

21 January 2018

1 reference

Lipid traffic: the ABC of transbilayer movement

21 January 2018

1 reference

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids

21 January 2018

1 reference

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

21 January 2018

1 reference

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

21 January 2018

1 reference

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

21 January 2018

1 reference

Cholesterol and the cell membrane

21 January 2018

1 reference

Modulation of membrane function by cholesterol.

21 January 2018

1 reference

The P-glycoprotein efflux pump: how does it transport drugs?

21 January 2018

1 reference

P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?).

21 January 2018

1 reference

Specific drug binding by purified lipid-reconstituted P-glycoprotein: dependence on the lipid composition

21 January 2018

1 reference

The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence

21 January 2018

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The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane

21 January 2018

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Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells

21 January 2018

1 reference

Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells.

21 January 2018

1 reference

Cholesterol: Coupling between membrane microenvironment and ABC transporter activity

21 January 2018

1 reference

Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis

21 January 2018

1 reference

P-glycoprotein in proteoliposomes with low residual detergent: the effects of cholesterol

21 January 2018

1 reference

Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport

21 January 2018

1 reference

P-glycoprotein inhibition by membrane cholesterol modulation

21 January 2018

1 reference

Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities

21 January 2018

1 reference

Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function.

21 January 2018

1 reference

Functional rafts in cell membranes

21 January 2018

1 reference

Lipid rafts: bringing order to chaos

21 January 2018

1 reference

The challenge of lipid rafts

21 January 2018

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Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences

21 January 2018

1 reference

Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

21 January 2018

1 reference

Cholesterol and the Golgi apparatus

21 January 2018

1 reference

Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association

21 January 2018

1 reference

N-glycans as apical sorting signals in epithelial cells

21 January 2018

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P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment

21 January 2018

1 reference

Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

21 January 2018

1 reference

Rituximab but not other anti-CD20 antibodies reverses multidrug resistance in 2 B lymphoma cell lines, blocks the activity of P-glycoprotein (P-gp), and induces P-gp to translocate out of lipid rafts

21 January 2018

1 reference

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

21 January 2018

1 reference

Insights on P-Glycoprotein's Efflux Mechanism Obtained by Molecular Dynamics Simulations.

21 January 2018

1 reference

Reversal of multidrug resistance by surfactants

21 January 2018

1 reference

Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells

21 January 2018

1 reference

Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers

21 January 2018

1 reference

Sucrose esters increase drug penetration, but do not inhibit p-glycoprotein in caco-2 intestinal epithelial cells

21 January 2018

1 reference

Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity

21 January 2018

1 reference

Modulation of P-glycoprotein-mediated multidrug resistance by acceleration of passive drug permeation across the plasma membrane

21 January 2018

1 reference

Detergents as intrinsic P-glycoprotein substrates and inhibitors.

21 January 2018

1 reference

P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity

21 January 2018

1 reference

Transport of LDS-751 from the cytoplasmic leaflet of the plasma membrane by the rhodamine-123-selective site of P-glycoprotein.

21 January 2018

1 reference

The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake.

21 January 2018

1 reference

Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

21 January 2018

1 reference

The remarkable transport mechanism of P-glycoprotein: a multidrug transporter

21 January 2018

1 reference

How hydrogen bonds impact P-glycoprotein transport and permeability.

21 January 2018

1 reference

Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein.

21 January 2018

1 reference

Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance

21 January 2018

1 reference

Presence of anionic phospholipids rules the membrane localization of phenothiazine type multidrug resistance modulator.

21 January 2018

1 reference

Phase separation in phosphatidylcholine membrane caused by the presence of a pyrimidine analogue of fluphenazine with high anti-multidrug-resistance activity

21 January 2018

1 reference

Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol

21 January 2018

1 reference

Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions

21 January 2018

1 reference

Lipid raft modulation by Rp1 reverses multidrug resistance via inactivating MDR-1 and Src inhibition

21 January 2018

1 reference

Vinegar-baked Radix Bupleuri modulates the cell membrane constituents and inhibits the P-gp activity in rat hepatocytes

21 January 2018

1 reference

Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity

21 January 2018

1 reference

P-glycoprotein senses its substrates and the lateral membrane packing density: consequences for the catalytic cycle

21 January 2018

1 reference

The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells

21 January 2018

1 reference

Compartmental models for apical efflux by P-glycoprotein--part 1: evaluation of model complexity

21 January 2018

1 reference

Compartmental models for apical efflux by P-glycoprotein: part 2--a theoretical study on transporter kinetic parameters

21 January 2018

1 reference

Can long range mechanical interaction between drugs and membrane proteins define the notion of molecular promiscuity? Application to P-glycoprotein-mediated multidrug resistance (MDR).

21 January 2018

1 reference

Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide

21 January 2018

1 reference

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

21 January 2018

1 reference

Liposomal sphingomyelin influences the cellular lipid profile of human lymphoblastic leukemia cells without effect on P-glycoprotein activity.

21 January 2018

1 reference

Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study

21 January 2018

1 reference

Biodegradable cationic polymeric nanocapsules for overcoming multidrug resistance and enabling drug-gene co-delivery to cancer cells

21 January 2018

1 reference

Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin

21 January 2018

1 reference

Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin

21 January 2018

1 reference

Localization of Multidrug Transporter Substrates within Model Membranes†

21 January 2018

1 reference