P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment (Q44982216)

7 December 2017

P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment (English)

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7 December 2017

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3

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7 December 2017

Szabolcs Modok

1

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PubMed ID

15258203

7 December 2017

Catherine Heyward

series ordinal

2

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7 December 2017

16 July 2004

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Journal of Lipid Research

7 December 2017

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7 December 2017

45

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7 December 2017

1910-1918

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7 December 2017

10

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

7 December 2017

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

P-glycoprotein-mediated Hoechst 33342 transport out of the lipid bilayer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Altered plasma membrane ultrastructure in multidrug-resistant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Ultrastructural alterations in plasma membranes from drug-resistant P388 murine leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Structure and origin of ordered lipid domains in biological membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Sphingomyelin: biophysical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Lateral diffusion in the liquid phases of dimyristoylphosphatidylcholine/cholesterol lipid bilayers: a free volume analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Liquid-crystalline phases of cholesterol/lipid bilayers as revealed by the fluorescence of trans-parinaric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Evidence for ADP release as the rate-limiting step in the catalytic cycle and its modulation by substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Lipid domains in model and biological membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

The effects of lipids and detergents on ATPase-active P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Physical principles of membrane organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Intermolecular interactions with/within cell membranes and the trinity of membrane potentials: kinetics and imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Interaction of Cholesterol with a Docosahexaenoic Acid-Containing Phosphatidylethanolamine: Trigger for Microdomain/Raft Formation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M400220-JLR200

10.1194/JLR.M400220-JLR200

21 January 2018

Identifiers

DOI

1 reference

7 December 2017

1 reference

PubMed ID

15258203