Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? (Q38530348)

3 September 2017

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title

Fractalkine in the nervous system: neuroprotective or neurotoxic molecule? (English)

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3 September 2017

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Myriam Catalano

2

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Flavia Trettel

object named as

Flavia Trettel

series ordinal

3

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author name string

Clotilde Lauro

series ordinal

1

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3 September 2017

Cristina Limatola

series ordinal

4

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3 September 2017

language of work or name

English

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publication date

17 June 2015

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Annals of the New York Academy of Sciences

3 September 2017

published in

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3 September 2017

volume

1351

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3 September 2017

page(s)

141-148

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Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

3 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes

21 January 2018

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

21 January 2018

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Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia

21 January 2018

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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

A new class of membrane-bound chemokine with a CX3C motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Layer V cortical neurons require microglial support for survival during postnatal development.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Synaptic pruning by microglia is necessary for normal brain development

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

21 January 2018

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Production and neuroprotective functions of fractalkine in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Neuronal 'On' and 'Off' signals control microglia

21 January 2018

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Microglial physiology: unique stimuli, specialized responses

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12805

Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Control of microglial neurotoxicity by the fractalkine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine promotes chemotaxis of bone marrow-derived mesenchymal stem cells towards ischemic brain lesions through Jak2 signaling and cytoskeletal reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine/CX3CL1 engages different neuroprotective responses upon selective glutamate receptor overactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine (CX3CL1) enhances hippocampal N-methyl-D-aspartate receptor (NMDAR) function via D-serine and adenosine receptor type A2 (A2AR) activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Phagocytosis of microglia in the central nervous system diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

MFG-E8 regulates microglial phagocytosis of apoptotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Fractalkine/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Increased placental growth factor in cerebrospinal fluid of patients with epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Role of fractalkine-CX3CR1 pathway in seizure-induced microglial activation, neurodegeneration, and neuroblast production in the adult rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Chemokines in systemic lupus erythematosus involving the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Higher plasma fractalkine is associated with better 6-month outcome from ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

The temporal dynamics of plasma fractalkine levels in ischemic stroke: association with clinical severity and outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12805

21 January 2018

Identifiers

DOI

10.1111/NYAS.12805

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3 September 2017

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