Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014). (Q38539470)

3 September 2017

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title

Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014). (English)

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3 September 2017

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Yung-Fong Tsai

1

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PubMed ID

26118988

3 September 2017

Tsong-Long Hwang

series ordinal

2

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PubMed ID

26118988

3 September 2017

language of work or name

English

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publication date

29 June 2015

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Expert Opinion on Therapeutic Patents

3 September 2017

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3 September 2017

25

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3 September 2017

10

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3 September 2017

1145-1158

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How human neutrophils kill and degrade microbes: an integrated view

3 September 2017

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https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The neutrophil in chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Degradation of native type IV procollagen by human neutrophil elastase. Implications for leukocyte-mediated degradation of basement membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Proteases and lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The adult respiratory distress syndrome: definition and prognosis, pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Phosphodiesterase-4 inhibitors as a novel approach for the treatment of respiratory disease: cilomilast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Phosphodiesterase inhibitors for chronic obstructive pulmonary disease: what does the future hold?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Identification of elastase in human eosinophils: immunolocalization, isolation, and partial characterization.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil granules and secretory vesicles in inflammation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

NSP4, an elastase-related protease in human neutrophils with arginine specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase in cyclic and severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil serine proteases: potential key regulators of cell signalling during inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Role of mast cell and neutrophil proteases in airway secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The protease-antiprotease balance within the human lung: implications for the pathogenesis of emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Alpha-1-antitrypsin deficiency: biochemistry and clinical manifestations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Structure, function, and control of neutrophil proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Comparative effects of salmeterol, albuterol, and ipratropium on normal and impaired mucociliary function in sheep

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Augmentation therapy for alpha(1)-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

ONO-5046, a novel inhibitor of human neutrophil elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Unexpected active-site flexibility in the structure of human neutrophil elastase in complex with a new dihydropyrimidone inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Synthesis and evaluation of benzoxazinone derivatives on activity of human neutrophil elastase and on hemorrhagic shock-induced lung injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Structural basis of substrate specificity in the serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil extracellular traps kill bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil extracellular traps

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Epidemiology of invasive candidiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

New aspects on the structure of neutrophil extracellular traps from chronic obstructive pulmonary disease and in vitro generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

NET formation induced by Pseudomonas aeruginosa cystic fibrosis isolates measured as release of myeloperoxidase-DNA and neutrophil elastase-DNA complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Molecular mechanisms regulating NETosis in infection and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

Interplay of infections, autoimmunity, and immunosuppression in systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1061998

10.1517/13543776.2015.1061998

21 January 2018

Identifiers

DOI

1 reference

3 September 2017

1 reference

PubMed ID

26118988