AIRE: From promiscuous molecular partnerships to promiscuous gene expression (Q38602757)

4 September 2017

AIRE: From promiscuous molecular partnerships to promiscuous gene expression (English)

1 reference

4 September 2017

1

Jakub Abramson

1 reference

4 September 2017

Yael Goldfarb

2

1 reference

PubMed ID

26450177

4 September 2017

language of work or name

English

0 references

publication date

9 October 2015

1 reference

European Journal of Immunology

4 September 2017

1 reference

4 September 2017

46

1 reference

4 September 2017

1

1 reference

4 September 2017

22-33

1 reference

Cellular mechanisms of immunologic tolerance

4 September 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Positional cloning of the APECED gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Deletional tolerance mediated by extrathymic Aire-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Expression of Aire and the early wave of apoptosis in spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

DAXX is a new AIRE-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The autoimmune regulator (AIRE) is a DNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Localization of the APECED protein in distinct nuclear structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Evolutionarily conserved and divergent regions of the autoimmune regulator (Aire) gene: a comparative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The nuclear pore complex--structure and function at a glance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Aire's partners in the molecular control of immunological tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

APECED-causing mutations in AIRE reveal the functional domains of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Proteome analysis of human nuclear insoluble fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A mini review of MAR-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Chromosomal clustering of genes controlled by the aire transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Getting up to speed with transcription elongation by RNA polymerase II

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Transcriptional impact of Aire varies with cell type

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A role of DNA-PK for the metabolic gene regulation in response to insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

DNA topoisomerase IIalpha is required for RNA polymerase II transcription on chromatin templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Cooperative activation of transcription by autoimmune regulator AIRE and CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Autoimmune regulator is acetylated by transcription coactivator CBP/p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

PIAS proteins: pleiotropic interactors associated with SUMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Functional interaction of AIRE with PIAS1 in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

HIPK2: a versatile switchboard regulating the transcription machinery and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

The cohesin complex and its roles in chromosome biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

Pre-mRNA processing reaches back to transcription and ahead to translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

7 January 2021

The monopartite nuclear localization signal of autoimmune regulator mediates its nuclear import and interaction with multiple importin alpha molecules

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

7 January 2021

Mapping DNA-binding domains of the autoimmune regulator protein

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

7 January 2021

The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

7 January 2021

SnapShot: Histone-Modifying Enzymes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201545792

7 January 2021

Identifiers

DOI

10.1002/EJI.201545792

1 reference

release_7zz5fu6kmvc6letddk4qxn7cb4

4 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7zz5fu6kmvc6letddk4qxn7cb4

24 November 2022

mapped directly with Wikidata item

PubMed ID

26450177

1 reference

PubMed ID

26450177