GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates (Q38605928)

4 September 2017

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates (English)

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4 September 2017

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GDNF family receptor alpha like

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Growth differentiation factor 15

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positive regulation of protein kinase B signaling

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GDNF family receptor alpha like

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Growth differentiation factor 15

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author name string

Shannon E Mullican

1

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4 September 2017

Xiefan Lin-Schmidt

2

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4 September 2017

Chen-Ni Chin

3

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4 September 2017

Jose A Chavez

4

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4 September 2017

Jennifer L Furman

5

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4 September 2017

Anthony A Armstrong

6

1 reference

4 September 2017

Stephen C Beck

7

1 reference

4 September 2017

Victoria J South

8

1 reference

4 September 2017

Thai Q Dinh

9

1 reference

4 September 2017

Tanesha D Cash-Mason

10

1 reference

4 September 2017

Cassandre R Cavanaugh

11

1 reference

4 September 2017

Serena Nelson

12

1 reference

4 September 2017

Chichi Huang

13

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4 September 2017

Michael J Hunter

14

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4 September 2017

Shamina M Rangwala

15

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4 September 2017

language of work or name

English

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publication date

28 August 2017

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4 September 2017

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.4392

4 September 2017

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cites work

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21 January 2018

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21 January 2018

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Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

21 January 2018

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Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets

21 January 2018

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hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

21 January 2018

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Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity

21 January 2018

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Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.

21 January 2018

1 reference

TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator

21 January 2018

1 reference

The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract

21 January 2018

1 reference

Growth differentiation factor 15 predicts future insulin resistance and impaired glucose control in obese nondiabetic individuals: results from the XENDOS trial

21 January 2018

1 reference

Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI.

21 January 2018

1 reference

Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.

21 January 2018

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GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.

21 January 2018

1 reference

GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells

21 January 2018

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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

21 January 2018

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Identification, expression and functional characterization of the GRAL gene

21 January 2018

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Loss of neurturin in frog--comparative genomics study of GDNF family ligand-receptor pairs.

21 January 2018

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Internalization of glial cell-derived neurotrophic factor receptor GFR alpha 1 in the absence of the ret tyrosine kinase coreceptor

21 January 2018

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Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation

21 January 2018

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Targeting the TGFβ signalling pathway in disease

21 January 2018

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BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors

21 January 2018

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Structure of the ternary signaling complex of a TGF-beta superfamily member

21 January 2018

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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

21 January 2018

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Comparison of GFL–GFRα complexes: further evidence relating GFL bend angle to RET signalling

21 January 2018

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RET recognition of GDNF-GFRα1 ligand by a composite binding site promotes membrane-proximal self-association

21 January 2018

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The GDNF family: signalling, biological functions and therapeutic value

21 January 2018

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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.

21 January 2018

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Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes

21 January 2018

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Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model

21 January 2018

1 reference

Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age.

21 January 2018

1 reference

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-beta superfamily member, acts as a quality control determinant for correctly folded MIC-1.

21 January 2018

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An efficient route to human bispecific IgG.

21 January 2018

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Severe malaria is associated with parasite binding to endothelial protein C receptor

21 January 2018

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NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

21 January 2018

1 reference

7 January 2021

inferred from DOI database lookup

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

1 reference

7 January 2021

inferred from DOI database lookup

Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction

1 reference

7 January 2021

inferred from DOI database lookup

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28846097

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NM.4392

1 reference

4 September 2017

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