Ret proto-oncogene (Q415976)

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mammalian protein found in Homo sapiens
  • RET transforming sequence
  • cadherin-related family member 16
  • RET receptor tyrosine kinase
  • RET
  • rearranged during transfection
  • receptor tyrosine kinase
  • proto-oncogene tyrosine-protein kinase receptor Ret
  • ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
  • hydroxyaryl-protein kinase
  • cadherin family member 12
  • CUX1/RET fusion
  • proto-oncogene c-Ret
  • Proto-Oncogene Proteins c-ret
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Language Label Description Also known as
English
Ret proto-oncogene
mammalian protein found in Homo sapiens
  • RET transforming sequence
  • cadherin-related family member 16
  • RET receptor tyrosine kinase
  • RET
  • rearranged during transfection
  • receptor tyrosine kinase
  • proto-oncogene tyrosine-protein kinase receptor Ret
  • ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
  • hydroxyaryl-protein kinase
  • cadherin family member 12
  • CUX1/RET fusion
  • proto-oncogene c-Ret
  • Proto-Oncogene Proteins c-ret

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
GOA
curator
UniProt
UniProt protein ID
P07949
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth
GOA
curator
UniProt
UniProt protein ID
P07949
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
GOA
curator
UniProt
UniProt protein ID
P07949
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
GOA
curator
UniProt
UniProt protein ID
P07949
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
MEN2A-RET-induced cellular transformation by activation of STAT3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
retrieved
8 April 2019
stated in
Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07949
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE RET 211421 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D051096
subject named as
Proto-Oncogene Proteins c-ret
0 references
 
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