Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3. (Q38609949)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21868755%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Celecoxib promotes c-FLIP degradation through Akt-independent inhibition of GSK3 (English)

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11 February 2020

1

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11 February 2020

5

Fadlo R Khuri

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11 February 2020

author name string

Wei Cao

2

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11 February 2020

Ping Yue

3

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11 February 2020

Chunhai Hao

4

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11 February 2020

Shi-Yong Sun

6

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11 February 2020

language of work or name

English

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publication date

25 August 2011

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11 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21868755%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

volume

71

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11 February 2020

issue

19

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11 February 2020

page(s)

6270-6281

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Identification of an antiapoptotic protein complex at death receptors

11 February 2020

cites work

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The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.

6 September 2017

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Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells

6 September 2017

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6 September 2017

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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

6 September 2017

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Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy

6 September 2017

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

6 September 2017

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6 September 2017

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Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib

6 September 2017

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6 September 2017

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Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo.

6 September 2017

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6 September 2017

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Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy.

6 September 2017

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6 September 2017

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

6 September 2017

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An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

6 September 2017

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Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway

6 September 2017

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Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues

6 September 2017

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GSK3 takes centre stage more than 20 years after its discovery

6 September 2017

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6 September 2017

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The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2

6 September 2017

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Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells.

6 September 2017

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Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

14 September 2017

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Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells

14 September 2017

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Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

14 September 2017

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Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.

14 September 2017

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Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro.

14 September 2017

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3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells

14 September 2017

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Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers

14 September 2017

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Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer

14 September 2017

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Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line

14 September 2017

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Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

25 September 2017

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Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells

25 September 2017

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Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

25 September 2017

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S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

25 September 2017

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Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling

23 June 2018

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Targeting the protein kinase C family: are we there yet?

23 June 2018

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Cytokine-stimulated phosphorylation of GSK-3 is primarily dependent upon PKCs, not PKB.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185138

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

31 August 2018

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Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck

31 August 2018

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Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185138

Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185138

Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21868755

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CCAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction and ubiquitin/proteasome-mediated cellular FLICE-inhibitory protein down-regulation contribute to enhancement of tumor necrosis factor-related apoptosis-inducing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21868755

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-11-0838

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21868755%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

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11 February 2020

PubMed publication ID

21868755

1 reference