Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease (Q38616054)

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English	Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Genetic Deletion of Tumor Necrosis Factor-α Attenuates Amyloid-β Production and Decreases Amyloid Plaque Formation and Glial Response in the 5XFAD Model of Alzheimer's Disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Alzheimer's disease

0 references

author name string

Evi Paouri

1

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Ourania Tzara

2

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Sofia Zenelak

3

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Spiros Georgopoulos

4

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

publication date

17 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Journal of Alzheimer's Disease

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

Deciphering Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Neuroinflammation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Immune attack: the role of inflammation in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Inflammation, microglia, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

The role of microglia in amyloid clearance from the AD brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Treatment for Rheumatoid Arthritis and Risk of Alzheimer's Disease: A Nested Case-Control Analysis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Regulation of tumour necrosis factor signalling: live or let die

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Characterization of tumor necrosis factor-deficient mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Eosinophil contamination of thioglycollate-elicited peritoneal macrophage cultures skews the functional readouts of in vitro assays

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Trafficking and proteolytic processing of APP

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Decreased behavioral impairments in an Alzheimer mice model by interfering with TNF-alpha metabolism.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumour Necrosis Factor Modulation for Treatment of Alzheimerʼs Disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

ADAM-17: the enzyme that does it all.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Purification of ADAM 10 from bovine spleen as a TNFalpha convertase

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

1 reference

https://api.crossref.org/works/10.3233%2FJAD-170065

21 January 2018

Identifiers

10.3233/JAD-170065

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 September 2017

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