STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential. (Q38647432)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

STAT1 and IRF8 in Vascular Inflammation and Cardiovascular Disease: Diagnostic and Therapeutic Potential (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

main subject

inflammation

0 references

cardiovascular disease

1 reference

Stefan Chmielewski

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Anna Piaszyk-Borychowska

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

publication date

25 November 2015

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

International Reviews of Immunology

1 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

35

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

434-454

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

Projections of global mortality and burden of disease from 2002 to 2030

1 March 2020

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Inteferons pen the JAK-STAT pathway

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T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

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Metabolic endotoxemia initiates obesity and insulin resistance

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Endotoxemia is related to systemic inflammation and atherosclerosis in peritoneal dialysis patients

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Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation.

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High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice

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The roles of Toll-like receptors in atherosclerosis.

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Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation

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Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice

21 January 2018

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Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome

21 January 2018

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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

21 January 2018

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Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension.

21 January 2018

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Inflammation, immunity, and hypertension

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NO-independent regulatory site on soluble guanylate cyclase

21 January 2018

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IFN-gamma potentiates atherosclerosis in ApoE knock-out mice

21 January 2018

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Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts

21 January 2018

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Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- mice

21 January 2018

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Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity

21 January 2018

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Structural bases of unphosphorylated STAT1 association and receptor binding

21 January 2018

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STATs dimerize in the absence of phosphorylation

21 January 2018

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Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

21 January 2018

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Biology and significance of the JAK/STAT signalling pathways

21 January 2018

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Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain

21 January 2018

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Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle

21 January 2018

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Mechanisms of type-I- and type-II-interferon-mediated signalling

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Stats: transcriptional control and biological impact

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Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

21 January 2018

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Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

21 January 2018

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Regulation of STAT signaling by acetylation

21 January 2018

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The HAT/HDAC interplay: multilevel control of STAT signaling

21 January 2018

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Phosphorylation-acetylation switch in the regulation of STAT1 signaling

21 January 2018

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STAT1 signaling is not regulated by a phosphorylation-acetylation switch

21 January 2018

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SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

21 January 2018

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The interferon in TLR signaling: more than just antiviral

21 January 2018

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The yin and yang of type I interferon activity in bacterial infection

21 January 2018

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

21 January 2018

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STAT1 as a central mediator of IFNγ and TLR4 signal integration in vascular dysfunction

21 January 2018

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STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis

21 January 2018

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STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion.

21 January 2018

1 reference

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ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells

21 January 2018

1 reference

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Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells

21 January 2018

1 reference

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IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways

21 January 2018

1 reference

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A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes

21 January 2018

1 reference

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BATF-JUN is critical for IRF4-mediated transcription in T cells

21 January 2018

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Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages.

21 January 2018

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Compensatory dendritic cell development mediated by BATF-IRF interactions

21 January 2018

1 reference

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Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia

21 January 2018

1 reference

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Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome

21 January 2018

1 reference

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Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU.1 complex

21 January 2018

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Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation

21 January 2018

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Signal integration between IFNgamma and TLR signalling pathways in macrophages

21 January 2018

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Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

21 January 2018

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Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases

21 January 2018

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Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.

21 January 2018

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HMEC-1: establishment of an immortalized human microvascular endothelial cell line

21 January 2018

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Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development

21 January 2018

1 reference

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Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.

21 January 2018

1 reference

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Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic atherosclerosis in apolipoprotein E-knockout mice

21 January 2018

1 reference

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AP-1 and STAT-1 decoy oligodeoxynucleotides attenuate transplant vasculopathy in rat cardiac allografts

21 January 2018

1 reference

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Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells

21 January 2018

1 reference

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Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3.

21 January 2018

1 reference

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Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation

21 January 2018

1 reference

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A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels.

21 January 2018

1 reference

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STAT transcription in the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells

21 January 2018

1 reference

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Interferon regulatory factors in heart: stress response beyond inflammation

21 January 2018

1 reference

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Coronary heart disease in systemic lupus erythematosus is associated with interferon regulatory factor-8 gene variants

21 January 2018

1 reference

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Interferon regulatory factor 8 modulates phenotypic switching of smooth muscle cells by regulating the activity of myocardin.

21 January 2018

1 reference

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IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

21 January 2018

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Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.

21 January 2018

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Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions

21 January 2018

1 reference

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Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells

21 January 2018

1 reference

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Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Therapeutic modulators of STAT signalling for human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation

21 January 2018

1 reference

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In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Small-molecule inhibitors of signal transducer and activator of transcription 3 protect against angiotensin II-induced vascular dysfunction and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Loss of STAT1 is associated with increased aortic rupture in an experimental model of aortic dissection and aneurysm formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Comparative screening and validation as a novel tool to identify STAT-specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Oncotype DX(®) colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidence

21 January 2018

1 reference

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Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study

21 January 2018

1 reference

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A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Hematopoietic Interferon Regulatory Factor 8-Deficiency Accelerates Atherosclerosis in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2015.1087519

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

21 January 2018

1 reference

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10.3109/08830185.2015.1087519

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26606328%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference