Macrophages in atherosclerosis: a dynamic balance. (Q34368005)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995626%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Macrophages in atherosclerosis: a dynamic balance (English)

1 reference

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8 March 2020

1 reference

1 reference

1

1 reference

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8 March 2020

Frederick J. Sheedy

2

1 reference

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8 March 2020

Frederick J. Sheedy

3

1 reference

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8 March 2020

Edward A Fisher

4

1 reference

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8 March 2020

author name string

Frederick J Sheedy

2

1 reference

PubMed ID

23995626

1 August 2017

Frederick J Sheedy

3

1 reference

1 August 2017

2 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995626%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

8 March 2020

published in

1 reference

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8 March 2020

volume

13

1 reference

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8 March 2020

page(s)

709-721

1 reference

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8 March 2020

issue

10

1 reference

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

8 March 2020

cites work

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Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention

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Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

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6 July 2018

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Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

6 July 2018

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Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

6 July 2018

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Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction

6 July 2018

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Myocardial infarction accelerates atherosclerosis.

6 July 2018

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Regression of atherosclerosis is characterized by broad changes in the plaque macrophage transcriptome

6 July 2018

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Circulating levels of secretory- and lipoprotein-associated phospholipase A2 activities: relation to atherosclerotic plaques and future all-cause mortality

6 July 2018

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The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice

6 July 2018

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Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice

6 July 2018

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Macrophage autophagy plays a protective role in advanced atherosclerosis

6 July 2018

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Autophagy links inflammasomes to atherosclerotic progression.

6 July 2018

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Role of macrophage scavenger receptors in atherosclerosis

6 July 2018

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Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.

6 July 2018

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Endogenous apolipoprotein A-I stabilizes ATP-binding cassette transporter A1 and modulates Toll-like receptor 4 signaling in human macrophages.

6 July 2018

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The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

6 July 2018

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NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis

6 July 2018

1 reference

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Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages

6 July 2018

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Autophagy in atherosclerosis: a potential drug target for plaque stabilization

6 July 2018

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Atherosclerosis: current pathogenesis and therapeutic options

6 July 2018

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Therapeutic siRNA silencing in inflammatory monocytes in mice

6 July 2018

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Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging

6 July 2018

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Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism

6 July 2018

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Receptor-independent fluid-phase pinocytosis mechanisms for induction of foam cell formation with native low-density lipoprotein particles

6 July 2018

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Phenotypic modulation of macrophages in response to plaque lipids

6 July 2018

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The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes

6 July 2018

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Krüppel-like factor 4 regulates macrophage polarization

6 July 2018

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Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis

6 July 2018

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Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase

6 July 2018

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

6 July 2018

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Macrophages in the pathogenesis of atherosclerosis

6 July 2018

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Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway

6 July 2018

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Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression

6 July 2018

1 reference

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HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells

6 July 2018

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Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

6 July 2018

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Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.

6 July 2018

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Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques

6 July 2018

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The immune system in atherosclerosis

6 July 2018

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The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis

6 July 2018

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Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity

6 July 2018

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

6 July 2018

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Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress

6 July 2018

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Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

6 July 2018

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Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol.

6 July 2018

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ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis

6 July 2018

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

6 July 2018

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Nonresolving inflammation

6 July 2018

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Macrophage plasticity in experimental atherosclerosis

6 July 2018

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Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

6 July 2018

1 reference

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Monocytes in atherosclerosis: subsets and functions

6 July 2018

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

6 July 2018

1 reference

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Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis.

6 July 2018

1 reference

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Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses

6 July 2018

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GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

6 July 2018

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Lipoprotein modification by secretory phospholipase A(2) enzymes contributes to the initiation and progression of atherosclerosis.

6 July 2018

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Autophagy regulates lipid metabolism

6 July 2018

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Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.

6 July 2018

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CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

6 July 2018

1 reference

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Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

6 July 2018

1 reference

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Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions.

6 July 2018

1 reference

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

6 July 2018

1 reference

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Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis

6 July 2018

1 reference

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

6 July 2018

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Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages

6 July 2018

1 reference

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Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice

6 July 2018

1 reference

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Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II

6 July 2018

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Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications

6 July 2018

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

6 July 2018

1 reference

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Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

6 July 2018

1 reference

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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

6 July 2018

1 reference

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Scavenger receptors in atherosclerosis: beyond lipid uptake

6 July 2018

1 reference

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Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder

6 July 2018

1 reference

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Antioxidants: the good, the bad and the ugly

6 July 2018

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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

6 July 2018

1 reference

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Role of cholesterol and lipid organization in disease

6 July 2018

1 reference

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Modulation of atherosclerosis in mice by Toll-like receptor 2

6 July 2018

1 reference

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Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

6 July 2018

1 reference

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Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques

6 July 2018

1 reference

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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Atherosclerosis. the road ahead

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Atherosclerosis — An Inflammatory Disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Enhanced monocyte progenitor cell proliferation in bone marrow of hyperlipemic swine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Leukocytosis in rabbits with diet-induced atherosclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Caspase-1 deficiency decreases atherosclerosis in apolipoprotein E-null mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Dramatic remodeling of advanced atherosclerotic plaques of the apolipoprotein E-deficient mouse in a novel transplantation model.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4357520

Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation

9 December 2018

1 reference

Bone Marrow–Specific Deficiency of Nuclear Receptor Nur77 Enhances Atherosclerosis

31 March 2020

1 reference

Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome

31 March 2020

1 reference

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

31 March 2020

1 reference

Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

31 March 2020

1 reference

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

31 March 2020

1 reference

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

31 March 2020

1 reference

Lipid clearance from fatty streak lesions by foam cell migration

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23995626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23995626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3520

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995626%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23995626%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference