The immune response in atherosclerosis: a double-edged sword (Q36508676)

14 August 2017

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title

The immune response in atherosclerosis: a double-edged sword (English)

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14 August 2017

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2

Peter Libby

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14 August 2017

Göran K Hansson

1

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14 August 2017

16 June 2006

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Nature Reviews Immunology

14 August 2017

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14 August 2017

6

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14 August 2017

508-519

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14 August 2017

7

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Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

14 August 2017

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Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque

31 March 2020

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S-100 positive cells in human arterial intima and in atherosclerotic lesions

31 March 2020

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Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction

31 March 2020

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Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis

31 March 2020

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

31 March 2020

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Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

31 March 2020

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Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice

31 March 2020

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Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

31 March 2020

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Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse

31 March 2020

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Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

31 March 2020

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Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

31 March 2020

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Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

31 March 2020

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The combined role of P- and E-selectins in atherosclerosis

31 March 2020

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A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

31 March 2020

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Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

31 March 2020

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Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

31 March 2020

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Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells

31 March 2020

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Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation

31 March 2020

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Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atherosclerotic lesions

31 March 2020

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Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice

31 March 2020

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Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.

31 March 2020

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Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis

31 March 2020

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Low density lipoprotein oxidation and its pathobiological significance

31 March 2020

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Scavenger receptors in innate immunity

31 March 2020

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The macrophage scavenger receptor type A directs modified proteins to antigen presentation

31 March 2020

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Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

31 March 2020

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The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

31 March 2020

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Innate immune recognition

31 March 2020

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Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation

31 March 2020

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Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells

31 March 2020

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Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL.

31 March 2020

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Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells

31 March 2020

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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

31 March 2020

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

31 March 2020

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Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice

31 March 2020

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Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization

31 March 2020

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Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

31 March 2020

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MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

31 March 2020

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T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein

31 March 2020

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Unstable atherosclerotic plaques contain T-cells that respond to Chlamydia pneumoniae

31 March 2020

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Low density lipoprotein undergoes oxidative modification in vivo

31 March 2020

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Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma

31 March 2020

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Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

31 March 2020

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LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis

31 March 2020

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Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

31 March 2020

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Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.

31 March 2020

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Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout mice

31 March 2020

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CD1d-dependent activation of NKT cells aggravates atherosclerosis.

31 March 2020

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CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells

31 March 2020

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Natural killer T cells accelerate atherogenesis in mice.

31 March 2020

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Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.

31 March 2020

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Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

31 March 2020

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IFN-gamma potentiates atherosclerosis in ApoE knock-out mice

31 March 2020

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Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse

31 March 2020

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The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice

31 March 2020

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Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

31 March 2020

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Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice

31 March 2020

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T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

31 March 2020

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Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- mice

31 March 2020

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In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice

31 March 2020

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Variation in susceptibility to atherosclerosis among inbred strains of mice

31 March 2020

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T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia

31 March 2020

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Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma

31 March 2020

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Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice

31 March 2020

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Inhibition of endothelial cell proliferation by gamma-interferon

31 March 2020

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Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells

31 March 2020

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Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.

31 March 2020

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Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells

31 March 2020

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Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease.

31 March 2020

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Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men.

31 March 2020

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Cachectin and tumour necrosis factor as two sides of the same biological coin

31 March 2020

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Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor.

31 March 2020

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Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis

31 March 2020

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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

31 March 2020

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Reduction of atherosclerosis in mice by inhibition of CD40 signalling

31 March 2020

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Requirement for CD154 in the progression of atherosclerosis.

31 March 2020

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Protective Role of Interleukin-10 in Atherosclerosis

31 March 2020

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Interleukin-10 blocks atherosclerotic events in vitro and in vivo

31 March 2020

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Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice.

31 March 2020

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The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis

31 March 2020

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Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice.

31 March 2020

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Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression

31 March 2020

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Disruption of TGF-β signaling in T cells accelerates atherosclerosis

31 March 2020

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Specific abrogation of transforming growth factor-beta signaling in T cells alters atherosclerotic lesion size and composition in mice.

31 March 2020

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Natural regulatory T cells control the development of atherosclerosis in mice

31 March 2020

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Autoantibody against oxidised LDL and progression of carotid atherosclerosis

31 March 2020

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Identification of immune responses against aldehyde-modified peptide sequences in apoB associated with cardiovascular disease

31 March 2020

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Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo

31 March 2020

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Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression

31 March 2020

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Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis

31 March 2020

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Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis

31 March 2020

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Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

31 March 2020

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Stabilization of atherosclerotic plaques: new mechanisms and clinical targets

31 March 2020

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Localization of stromelysin gene expression in atherosclerotic plaques by in situ hybridization

31 March 2020

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Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques

31 March 2020

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Atherosclerosis and proteinase activation

31 March 2020

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CD40 ligand is selectively expressed on CD4+ T cells and platelets: implications for CD40–CD40L signalling in atherosclerosis

31 March 2020

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Overcoming restenosis with sirolimus: from alphabet soup to clinical reality

31 March 2020

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Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury

31 March 2020

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Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

31 March 2020

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C-reactive protein levels and outcomes after statin therapy

31 March 2020

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Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

31 March 2020

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Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

31 March 2020

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Statins as a newly recognized type of immunomodulator

31 March 2020

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Metaanalysis of statins and survival in de novo cardiac transplantation

31 March 2020

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Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial

31 March 2020

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The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

31 March 2020

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PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis

31 March 2020

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Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.

31 March 2020

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Coxibs and cardiovascular disease

31 March 2020

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Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention

31 March 2020

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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.

31 March 2020

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The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

31 March 2020

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C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

31 March 2020

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C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

31 March 2020

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Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis

31 March 2020

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Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits

31 March 2020

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Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis.

31 March 2020

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Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes

31 March 2020

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Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences

31 March 2020

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Adoptive transfer of CD4+ T cells reactive to modified low-density lipoprotein aggravates atherosclerosis.

31 March 2020

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Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis

31 March 2020

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Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions

31 March 2020

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Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice

31 March 2020

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Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I

31 March 2020

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T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1882

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14 August 2017

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PubMed ID

16778830