Tau and neurodegenerative disease: the story so far. (Q38658752)

5 September 2017

Tau and neurodegenerative disease: the story so far. (English)

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5 September 2017

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3

Cheng-Xin Gong

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5 September 2017

Khalid Iqbal

1

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5 September 2017

Fei Liu

series ordinal

2

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5 September 2017

language of work or name

English

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publication date

4 December 2015

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5 September 2017

Nature Reviews Neurology

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5 September 2017

12

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5 September 2017

15-27

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5 September 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2015.225

5 September 2017

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An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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Regulation of phosphorylation of tau by protein kinases in rat brain

21 January 2018

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Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

21 January 2018

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Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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Tau is essential to beta -amyloid-induced neurotoxicity

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Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.

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Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

21 January 2018

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Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease

21 January 2018

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Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments

21 January 2018

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

21 January 2018

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Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

21 January 2018

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

21 January 2018

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Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

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Structural characterization of the core of the paired helical filament of Alzheimer disease

21 January 2018

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Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

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Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.

21 January 2018

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Advanced Maillard reaction end products are associated with Alzheimer disease pathology

21 January 2018

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Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer's disease.

21 January 2018

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O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

21 January 2018

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Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.

21 January 2018

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Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

21 January 2018

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Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

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The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

21 January 2018

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Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

21 January 2018

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Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

21 January 2018

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Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation

21 January 2018

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Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

21 January 2018

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First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model

21 January 2018

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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

21 January 2018

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Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

21 January 2018

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Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

21 January 2018

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Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

21 January 2018

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Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.

21 January 2018

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Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

21 January 2018

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

21 January 2018

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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

21 January 2018

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Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases.

21 January 2018

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Non-proline-dependent protein kinases phosphorylate several sites found in tau from Alzheimer disease brain.

21 January 2018

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

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Ser-262 in human recombinant tau protein is a markedly more favorable site for phosphorylation by CaMKII than PKA or PhK.

21 January 2018

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Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3.

21 January 2018

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Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases.

21 January 2018

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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

21 January 2018

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Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

21 January 2018

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PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

21 January 2018

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Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

21 January 2018

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Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

21 January 2018

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Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

21 January 2018

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Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.

21 January 2018

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Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

21 January 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

21 January 2018

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Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

21 January 2018

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Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

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Tau pathology in Alzheimer disease and other tauopathies

21 January 2018

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Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

21 January 2018

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Regulation of alternative splicing of tau exon 10.

21 January 2018

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Protein phosphatase 2A: a panoply of enzymes.

21 January 2018

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Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12

21 January 2018

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21 January 2018

12 December 2020

Identification of a new family of protein phosphatase 2A regulatory subunits

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

21 January 2018

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A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

21 January 2018

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

21 January 2018

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

21 January 2018

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In vitro phosphorylation of the polyomavirus major capsid protein VP1 on serine 66 by casein kinase II.

21 January 2018

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Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.

21 January 2018

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The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

21 January 2018

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Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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TREM2 Variants in Alzheimer's Disease

21 January 2018

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

21 January 2018

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Autocatalytic activation of human legumain at aspartic acid residues

21 January 2018

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Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo

21 January 2018

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Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

21 January 2018

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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET

21 January 2018

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Neurodegenerative tauopathies

21 January 2018

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A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam

21 January 2018

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Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease

21 January 2018

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Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

21 January 2018

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Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

21 January 2018

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Distinct tau prion strains propagate in cells and mice and define different tauopathies

21 January 2018

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Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

21 January 2018

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Propagation of tau pathology in a model of early Alzheimer's disease

21 January 2018

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Trans-synaptic spread of tau pathology in vivo

21 January 2018

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

21 January 2018

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Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

21 January 2018

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Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders

21 January 2018

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Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease.

21 January 2018

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Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Tau-aggregation inhibitor therapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Tau immunotherapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

NAP alpha-aminoisobutyric acid (IsoNAP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Failure of neuronal maturation in Alzheimer disease dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Granular tau oligomers as intermediates of tau filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Alzheimer neurofibrillary tangles: monoclonal antibodies to inherent antigen(s)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Lipoperoxidation is selectively involved in progressive supranuclear palsy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

A phase II trial of tideglusib in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2015.225

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

31 March 2020

1 reference

12 December 2020

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

1 reference

12 December 2020

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study

1 reference

12 December 2020

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1 reference

12 December 2020

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain

1 reference

12 December 2020

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1 reference

12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

12 December 2020

Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II.

1 reference

12 December 2020

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments

1 reference

12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1 reference

12 December 2020

Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase

1 reference

12 December 2020

Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein

1 reference

12 December 2020

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

1 reference

12 December 2020

10.1038/NRNEUROL.2015.225

Identifiers

DOI

1 reference

Dimensions Publication ID

5 September 2017

1042839315

0 references

Fatcat ID

release_ssk6yrl7qbelrnkfn56evrekcm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ssk6yrl7qbelrnkfn56evrekcm

24 November 2022

mapped directly with Wikidata item

1 reference