A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease (Q38672340)

5 September 2017

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease (English)

1 reference

single cell transcriptomics

5 September 2017

0 references

0 references

0 references

1 reference

A curated database reveals trends in single-cell transcriptomics

reference URL

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

1

Hadas Keren-Shaul

1 reference

5 September 2017

Orit Matcovitch-Natan

series ordinal

4

object named as

Orit Matcovitch-Natan

0 references

Marco Colonna

series ordinal

12

object named as

Marco Colonna

1 reference

5 September 2017

14

Ido Amit

1 reference

5 September 2017

8

Kuti Baruch

1 reference

5 September 2017

13

Michal Schwartz

1 reference

5 September 2017

11

Shalev Itzkovitz

1 reference

5 September 2017

7

Eyal David

1 reference

5 September 2017

6

Tyler K Ulland

1 reference

5 September 2017

2

Amit Spinrad

1 reference

5 September 2017

9

David Lara-Astaiso

1 reference

5 September 2017

3

Assaf Weiner

1 reference

5 September 2017

Raz Dvir-Szternfeld

5

1 reference

5 September 2017

Beata Toth

series ordinal

10

1 reference

5 September 2017

language of work or name

English

0 references

publication date

7 June 2017

1 reference

external data available at URL

5 September 2017

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98969

1 reference

A curated database reveals trends in single-cell transcriptomics

reference URL

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

1 reference

5 September 2017

169

1 reference

5 September 2017

1276-1290.e17

1 reference

5 September 2017

7

1 reference

describes a project that uses

5 September 2017

brain

1 reference

A curated database reveals trends in single-cell transcriptomics

https://www.nxn.se/single-cell-studies/data.tsv

7 February 2021

reference URL

cites work

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

1 reference

19 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.CELL.2016.09.027

Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

2 references

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.AAA1934

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells

2 references

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.1245316

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

2 references

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE13173

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Surveillance, phagocytosis, and inflammation: how never-resting microglia influence adult hippocampal neurogenesis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Every cell is special: genome-wide studies add a new dimension to single-cell biology

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Origin of microglia: current concepts and past controversies

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Differential roles of microglia and monocytes in the inflamed central nervous system

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Immunogenetics. Chromatin state dynamics during blood formation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Unravelling mononuclear phagocyte heterogeneity

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Stochastic gene expression in a single cell

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 and the neuroimmunology of Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Systemic inflammatory cells fight off neurodegenerative disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Latent enhancers activated by stimulation in differentiated cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Factors regulating microglia activation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Lipoprotein lipase mutations and Alzheimer's disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer's Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The dynamics of monocytes and microglia in Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The H+ allele of the lipoprotein lipase (LPL) HindIII intronic polymorphism and the risk for sporadic late-onset Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglia development follows a stepwise program to regulate brain homeostasis.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Immune attack: the role of inflammation in Alzheimer disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 Variants in Alzheimer's Disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglia in the developing brain: from immunity to behaviour

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Alzheimer's disease: the challenge of the second century

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Targeting neuroinflammation in Alzheimer's disease: evidence for NSAIDs and novel therapeutics

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Optimality in the development of intestinal crypts

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Macrophages as APC and the dendritic cell myth

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Therapeutic effects of glatiramer acetate and grafted CD115⁺ monocytes in a mouse model of Alzheimer's disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The microglial sensome revealed by direct RNA sequencing

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Brain-immune communication pathways

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Single-cell messenger RNA sequencing reveals rare intestinal cell types

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

HISAT: a fast spliced aligner with low memory requirements

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The myeloid cells of the central nervous system parenchyma

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TYROBP in Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The Role of immune and inflammatory mechanisms in ALS.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 in CNS homeostasis and neurodegenerative disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

The role of microglia in the healthy brain.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types

2 references

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.1247651

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TYROBP genetic variants in early-onset Alzheimer's disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Walking the tightrope: proteostasis and neurodegenerative disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglia in Alzheimer's disease: the good, the bad and the ugly

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Cutting Edge: TREM-2 Attenuates Macrophage Activation

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Making the case for chromatin profiling: a new tool to investigate the immune-regulatory landscape.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Specification of tissue-resident macrophages during organogenesis.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Revisiting the Mechanisms of CNS Immune Privilege

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Microglial dysfunction in brain aging and Alzheimer's disease

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2017.05.018

Identifiers

DOI

10.1016/J.CELL.2017.05.018

1 reference

5 September 2017

1 reference