TREM2 variants: new keys to decipher Alzheimer disease pathogenesis (Q38748724)

6 September 2017

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis (English)

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6 September 2017

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6 September 2017

Yaming Wang

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PubMed ID

26911435

6 September 2017

language of work or name

English

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publication date

25 February 2016

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Nature Reviews Neuroscience

6 September 2017

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6 September 2017

17

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6 September 2017

4

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6 September 2017

201-207

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https://scigraph.springernature.com/pub.10.1038/nrn.2016.7

6 September 2017

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cites work

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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TREM2 and Neurodegenerative Disease

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TREM2 is associated with the risk of Alzheimer's disease in Spanish population

31 March 2020

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Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia.

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

31 March 2020

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The TREM receptor family and signal integration

31 March 2020

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TREM and TREM-like receptors in inflammation and disease

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Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

31 March 2020

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Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

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Impaired differentiation of osteoclasts in TREM-2-deficient individuals

31 March 2020

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DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

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TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

31 March 2020

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TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

31 March 2020

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

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Efficient colonic mucosal wound repair requires Trem2 signaling

31 March 2020

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Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family

31 March 2020

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

31 March 2020

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Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors

31 March 2020

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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.

31 March 2020

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RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.

31 March 2020

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Pattern recognition by TREM-2: binding of anionic ligands

31 March 2020

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Specific lipid recognition is a general feature of CD300 and TREM molecules.

31 March 2020

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TREM2 sustains microglial expansion during aging and response to demyelination

31 March 2020

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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

31 March 2020

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TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

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Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

31 March 2020

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Insights into TREM2 biology by network analysis of human brain gene expression data

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

31 March 2020

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The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.

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CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts

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Myeloid cells in Alzheimer's disease: culprits, victims or innocent bystanders?

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Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

31 March 2020

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

31 March 2020

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Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

31 March 2020

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRN.2016.7

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRN.2016.7

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

31 March 2020

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRN.2016.7

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

31 March 2020

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Missense variant in TREML2 protects against Alzheimer's disease

31 March 2020

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A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology

31 March 2020

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CD33 modulates TREM2: convergence of Alzheimer loci.

31 March 2020

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TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRN.2016.7

Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease

31 March 2020

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TREM2 and Risk of Alzheimer's Disease--Friend or Foe?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 enables amyloid β clearance by microglia

31 March 2020

1 reference

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Development and homeostasis of "resident" myeloid cells: the case of the microglia

31 March 2020

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Regulation of microglia development and homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRN.2016.7

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

The microglial sensome revealed by direct RNA sequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Homeostatic and injury-induced microglia behavior in the aging brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Microglial senescence: does the brain's immune system have an expiration date?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Heterozygous TREM2 mutations in frontotemporal dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2 regulates microglial cell activation in response to demyelination in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Attenuated inflammatory response in triggering receptor expressed on myeloid cells 2 (TREM2) knock-out mice following stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRN.2016.7

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26911435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alzheimer's disease: the challenge of the second century

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26911435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TREM2 and neurodegenerative disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26911435

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRN.2016.7

1 reference

PubMed ID

26911435

Dimensions Publication ID

6 September 2017

0 references

1 reference

PubMed ID

26911435