PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration (Q38672664)

1 July 2019

title

PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration (English)

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1 July 2019

main subject

endoplasmic reticulum

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2

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1 July 2019

author name string

Michelle C Bell

series ordinal

1

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1 July 2019

Alexandria L Ingram

series ordinal

3

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1 July 2019

Jose F Abisambra

series ordinal

4

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1 July 2019

publication date

1 January 2016

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1 July 2019

Current Alzheimer Research

published in

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1 July 2019

volume

13

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1 July 2019

issue

2

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1 July 2019

page(s)

150-163

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1 July 2019

Prominent psychiatric features and early onset in an inherited prion disease with a new insertional mutation in the prion protein gene

cites work

1 reference

12 December 2020

RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Localization of the gene for a novel autosomal recessive neurodegenerative Huntington-like disorder to 4p15.3.

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12 December 2020

Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.

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12 December 2020

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

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12 December 2020

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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12 December 2020

Amyotrophic lateral sclerosis

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Huntington disease phenocopy is a familial prion disease

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12 December 2020

A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2.

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12 December 2020

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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12 December 2020

Higher order arrangement of the eukaryotic nuclear bodies

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12 December 2020

Orchestrating the unfolded protein response in health and disease

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12 December 2020

Endoplasmic reticulum stress and the development of diabetes: a review

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12 December 2020

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

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12 December 2020

Endoplasmic reticulum stress and diabetes mellitus.

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12 December 2020

The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice

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12 December 2020

Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia

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12 December 2020

Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment

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12 December 2020

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

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12 December 2020

Diseases of the basal ganglia. Their relation to disorders of movement.

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12 December 2020

BRAIN AND HEART CATECHOLAMINE LEVELS AFTER L-DOPA ADMINISTRATION IN RESERPINE TREATED MICE: CORRELATIONS WITH A CONDITIONED AVOIDANCE RESPONSE

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12 December 2020

SUBSTANTIA NIGRA AND PARKINSONISM.

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12 December 2020

Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy

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12 December 2020

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

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12 December 2020

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

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12 December 2020

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

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12 December 2020

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

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12 December 2020

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

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12 December 2020

The unfolded protein response is activated in Alzheimer's disease.

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12 December 2020

Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.

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12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

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12 December 2020

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

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12 December 2020

Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo

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12 December 2020

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery

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12 December 2020

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

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12 December 2020

Prognosis of amyotrophic lateral sclerosis with respiratory onset.

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12 December 2020

Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies.

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12 December 2020

The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion

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12 December 2020

Alzheimer's disease affects limbic nuclei of the thalamus

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12 December 2020

Reexamination of granulovacuolar degeneration

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12 December 2020

Activation of the unfolded protein response in Parkinson's disease.

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12 December 2020

How common are the "common" neurologic disorders?

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12 December 2020

ER stress and diseases.

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12 December 2020

Norepinephrine: The redheaded stepchild of Parkinson's disease

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12 December 2020

Neuropathological stageing of Alzheimer-related changes

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12 December 2020

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

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12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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12 December 2020

How IRE1 reacts to ER stress

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12 December 2020

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

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12 December 2020

Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation

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12 December 2020

Huntington disease-like 2: the first patient with apparent European ancestry.

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12 December 2020

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

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12 December 2020

Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK

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12 December 2020

A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro

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12 December 2020

Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death

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12 December 2020

De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala

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12 December 2020

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

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12 December 2020

Divergent effects of PERK and IRE1 signaling on cell viability

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12 December 2020

The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

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12 December 2020

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

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12 December 2020

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

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12 December 2020

Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway

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12 December 2020

Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

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12 December 2020

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

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12 December 2020

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

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12 December 2020

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

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12 December 2020

Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families

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12 December 2020

LDLR expression and localization are altered in mouse and human cell culture models of Alzheimer's disease

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12 December 2020

Expression of heat shock proteins in Alzheimer's disease

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12 December 2020

Calcium dysregulation in amyotrophic lateral sclerosis

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12 December 2020

Wolcott-Rallison syndrome due to the same mutation (W522X) in EIF2AK3 in two unrelated families and review of the literature.

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12 December 2020

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

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12 December 2020

Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

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12 December 2020

Regulation of translation by stress granules and processing bodies

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12 December 2020

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

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12 December 2020

A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

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12 December 2020

Neuropathology of variants of progressive supranuclear palsy

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12 December 2020

Upstream open reading frames: molecular switches in (patho)physiology

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12 December 2020

Granulovacuolar degeneration (GVD) bodies of Alzheimer's disease (AD) resemble late-stage autophagic organelles

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12 December 2020

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

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12 December 2020

Wolcott-Rallison syndrome

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12 December 2020

Structural determinants of PERK inhibitor potency and selectivity

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12 December 2020

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor

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12 December 2020

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

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12 December 2020

Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

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12 December 2020

Huntington's disease look-alikes

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12 December 2020

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

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12 December 2020

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

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12 December 2020

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

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12 December 2020

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

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12 December 2020

Huntington's Disease and Striatal Signaling.

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12 December 2020

A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density

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12 December 2020

Granulovacuolar degenerations appear in relation to hippocampal phosphorylated tau accumulation in various neurodegenerative disorders.

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12 December 2020

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies

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12 December 2020

The unfolded protein response: from stress pathway to homeostatic regulation

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12 December 2020

Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.

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12 December 2020

Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA.

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12 December 2020

DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

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12 December 2020

Sensing endoplasmic reticulum stress

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12 December 2020

TDP-43 aggregation in neurodegeneration: are stress granules the key?

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12 December 2020

GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins

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12 December 2020

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

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12 December 2020

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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12 December 2020

Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein

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12 December 2020

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

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12 December 2020

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

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12 December 2020

JNK3 perpetuates metabolic stress induced by Aβ peptides.

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12 December 2020

XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats

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12 December 2020

Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

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12 December 2020

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

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12 December 2020

Differentiation of progressive supranuclear palsy: clinical, imaging and laboratory tools.

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12 December 2020

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

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12 December 2020

Accuracy of the National Institute for Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy

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12 December 2020

2013 Alzheimer's disease facts and figures

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12 December 2020

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

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12 December 2020

Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles

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12 December 2020

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

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12 December 2020

An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease

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12 December 2020

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

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12 December 2020

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease

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12 December 2020

Endoplasmic reticulum stress: its role in disease and novel prospects for therapy

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12 December 2020

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

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12 December 2020

ER Dysfunction and Protein Folding Stress in ALS.

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12 December 2020

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

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12 December 2020

Endoplasmic reticulum stress associated responses in cancer

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12 December 2020

Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy

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12 December 2020

Differential loss of striatal projection neurons in Huntington disease

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12 December 2020

ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin

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12 December 2020

Frontotemporal lobar degeneration: current perspectives

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12 December 2020

HKH40A downregulates GRP78/BiP expression in cancer cells

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12 December 2020

Common variants in PERK, JNK, BIP and XBP1 genes are associated with the risk of prediabetes or diabetes-related phenotypes in a Chinese population.

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12 December 2020

Granulovacuolar degeneration and unfolded protein response in mouse models of tauopathy and Aβ amyloidosis.

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12 December 2020

A computational model of motor neuron degeneration

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12 December 2020

Therapeutic and diagnostic challenges for frontotemporal dementia

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12 December 2020

Parkinson's disease and age: The obvious but largely unexplored link.

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12 December 2020

The phenotypic variability of amyotrophic lateral sclerosis

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12 December 2020

Druggable sensors of the unfolded protein response

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12 December 2020

The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases

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12 December 2020

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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12 December 2020

Functional aspects of the role of catecholamines in the central nervous system

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12 December 2020

Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia

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12 December 2020

Possible role of brain dopamine.

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12 December 2020

Ultrastructural localization of amyloid protein precursor in the normal and postischemic gerbil brain

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Natural history of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) and clinical predictors of survival: a clinicopathological study

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

A Huntington disease-like neurodegenerative disorder maps to chromosome 20p.

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

10.2174/1567205013666151218145431

Identifiers

DOI

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1 July 2019

release_xi4i2fsnjjdine7ofpr2wurrhm

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/xi4i2fsnjjdine7ofpr2wurrhm

24 November 2022

mapped directly with Wikidata item

PMCID

6542591

1 reference

1 July 2019

PubMed ID

26679859

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1 July 2019