Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors. (Q38673602)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

Pancras C.W. Hogendoorn

8

1 reference

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27 February 2020

Peter Devilee

14

1 reference

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27 February 2020

Judith Bovée

16

1 reference

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27 February 2020

11

Esther Korpershoek

1 reference

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27 February 2020

author name string

Attje S Hoekstra

1

1 reference

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27 February 2020

Marieke A de Graaff

2

1 reference

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27 February 2020

Inge H Briaire-de Bruijn

3

1 reference

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27 February 2020

Cor Ras

4

1 reference

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27 February 2020

Reza Maleki Seifar

5

1 reference

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27 February 2020

Ivonne van Minderhout

6

1 reference

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27 February 2020

Cees J Cornelisse

7

1 reference

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27 February 2020

Martijn H Breuning

9

1 reference

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27 February 2020

Johnny Suijker

10

1 reference

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27 February 2020

Henricus P M Kunst

12

1 reference

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27 February 2020

Norma Frizzell

13

1 reference

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27 February 2020

Jean-Pierre Bayley

15

1 reference

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27 February 2020

language of work or name

English

0 references

publication date

1 November 2015

1 reference

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27 February 2020

1 reference

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27 February 2020

volume

6

1 reference

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27 February 2020

issue

36

1 reference

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27 February 2020

page(s)

38777-38788

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json

Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry.

27 February 2020

cites work

1 reference

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Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB/D-related paraganglioma: initial experimental and ex vivo findings

6 September 2017

1 reference

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5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

6 September 2017

1 reference

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Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

6 September 2017

1 reference

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Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency

6 September 2017

1 reference

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

6 September 2017

1 reference

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

6 September 2017

1 reference

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Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

6 September 2017

1 reference

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The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

6 September 2017

1 reference

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

6 September 2017

1 reference

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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

6 September 2017

1 reference

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SDHA is a tumor suppressor gene causing paraganglioma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

6 September 2017

1 reference

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6 September 2017

1 reference

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Histone demethylation by a family of JmjC domain-containing proteins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Inherited susceptibility to uterine leiomyomas and renal cell cancer

6 September 2017

1 reference

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Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

6 September 2017

1 reference

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Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

14 September 2017

1 reference

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Germline FH mutations presenting with pheochromocytoma.

14 September 2017

1 reference

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HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Hereditary leiomyomatosis and renal cell cancer in families referred for fumarate hydratase germline mutation analysis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas

23 June 2018

1 reference

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SDH mutations establish a hypermethylator phenotype in paraganglioma.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics

31 August 2018

1 reference

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Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Multiparameter DNA flow-sorting demonstrates diploidy and SDHD wild-type gene retention in the sustentacular cell compartment of head and neck paragangliomas: chief cells are the only neoplastic component

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Increased HIF1α in SDH and FH deficient tumors does not cause microsatellite instability

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4770736

Paragangliomas of the head and neck region show complete loss of heterozygosity at 11 q22-q23 in chief cells and the flow-sorted dna aneuploid fraction

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26472283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Loss of heterozygosity and DNA ploidy point to a diverging genetic mechanism in the origin of peripheral and central chondrosarcoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26472283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26472283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.6091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26472283%20AND%20SRC:MED&resulttype=core&format=json